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MK-801 inhibits the development of morphine tolerance at spinal sites
dc.contributor.authorGutstein, Howard B.en_US
dc.contributor.authorTrujillo, Keith A.en_US
dc.date.accessioned2006-04-10T15:32:58Z
dc.date.available2006-04-10T15:32:58Z
dc.date.issued1993-10-29en_US
dc.identifier.citationGutstein, Howard B., Trujillo, Keith A. (1993/10/29)."MK-801 inhibits the development of morphine tolerance at spinal sites." Brain Research 626(1-2): 332-334. <http://hdl.handle.net/2027.42/30508>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6SYR-483ST6D-222/2/f6ff621ae220a6c63d04f2c2ecc8e99aen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30508
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8281446&dopt=citationen_US
dc.description.abstractThe (NMDA) receptor antagonist MK-801 has been shown to attenuate tolerance development in rats. In this study, we show that MK-801 inhibits tolerance to the antinociceptive effects of morphine, as assessed by the tail-flick test, in spinalized rats. These results suggest that NMDA receptor antagonists inhibit opiate tolerance at spinal sites, and also provide strong evidence that the effects of MK-801 are not due to its ability to interfere with associative learning, but instead to inhibition of non-associative mechanisms of opiate tolerance.en_US
dc.format.extent288209 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleMK-801 inhibits the development of morphine tolerance at spinal sitesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI 48109-0800, USA; Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109-0800, USA.en_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, MI 48109-0800, USAen_US
dc.identifier.pmid8281446en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30508/1/0000137.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-8993(93)90597-Gen_US
dc.identifier.sourceBrain Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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