IGF receptor function and regulation in autocrine human neuroblastoma cell growth
dc.contributor.author | Martin, Donna M. | en_US |
dc.contributor.author | Singleton, J. Robinson | en_US |
dc.contributor.author | Meghani, Mihir A. | en_US |
dc.contributor.author | Feldman, Eva L. | en_US |
dc.date.accessioned | 2006-04-10T15:33:07Z | |
dc.date.available | 2006-04-10T15:33:07Z | |
dc.date.issued | 1993-10-20 | en_US |
dc.identifier.citation | Martin, Donna M., Singleton, J. Robinson, Meghani, Mihir A., Feldman, Eva L. (1993/10/20)."IGF receptor function and regulation in autocrine human neuroblastoma cell growth." Regulatory Peptides 48(1-2): 225-232. <http://hdl.handle.net/2027.42/30512> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0S-47GGSM5-RG/2/47dbae9b264b986eb5015719c086c292 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30512 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8265811&dopt=citation | en_US |
dc.description.abstract | Insulin-like growth factor-II (IGF-II) and its receptors (type I and II IGF receptors) are expressed in the nervous system in a tissue and developmentally specific manner. We have previously shown that SH-SY5Y human neuroblastoma cells synthesize and secrete high levels of IGF-II, and respond to it with increased neuritic outgrowth, DNA synthesis, and cell proliferation. SH-SY5Y cells also produce type I IGF and IGF-II/M6P receptors; however, it is not known whether these receptors mediate the observed growth promoting effects of IGF-II. In this study, we assayed the role of type I IGF receptor and IGF-II/M6P receptor expression in mediating autocrine IGF-II induced growth. Using anti-receptor antibodies, we found that IGF-II stimulates cell proliferation via the type I IGF receptor but not via the IGF-II/M6P receptor. By Northern analysis, we detected increased mRNA expression of both receptors, with more dramatic changes in type I IGF receptor expression. Collectively, our results indicate a role for the type I IGF receptor in mediating IGF-II induced autocrine neuroblastoma cell growth. | en_US |
dc.format.extent | 667499 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | IGF receptor function and regulation in autocrine human neuroblastoma cell growth | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Neuroscience Program, The University of Michigan, Ann Arbor, MI, USA; Department of Neurology, The University of Michigan, Ann Arbor, MI, USA. | en_US |
dc.contributor.affiliationum | Neuroscience Program, The University of Michigan, Ann Arbor, MI, USA; Department of Neurology, The University of Michigan, Ann Arbor, MI, USA. | en_US |
dc.contributor.affiliationum | Neuroscience Program, The University of Michigan, Ann Arbor, MI, USA; Department of Neurology, The University of Michigan, Ann Arbor, MI, USA. | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan, Ann Arbor, MI, USA; Neuroscience Program, The University of Michigan, Ann Arbor, MI, USA. | en_US |
dc.identifier.pmid | 8265811 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30512/1/0000142.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0167-0115(93)90351-8 | en_US |
dc.identifier.source | Regulatory Peptides | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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