Where does damage lead to enhanced food aversion: the ventral pallidum/substantia innominata or lateral hypothalamus?

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dc.contributor.author Cromwell, Howard C. en_US
dc.contributor.author Berridge, Kent C. en_US
dc.date.accessioned 2006-04-10T15:33:19Z
dc.date.available 2006-04-10T15:33:19Z
dc.date.issued 1993-10-08 en_US
dc.identifier.citation Cromwell, Howard C., Berridge, Kent C. (1993/10/08)."Where does damage lead to enhanced food aversion: the ventral pallidum/substantia innominata or lateral hypothalamus?." Brain Research 624(1-2): 1-10. <http://hdl.handle.net/2027.42/30517> en_US
dc.identifier.uri http://www.sciencedirect.com/science/article/B6SYR-482YWB9-91/2/01b4a04c2571d6fe40ac73fb771be9c3 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/30517
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8252379&dopt=citation en_US
dc.description.abstract It is well known that lesions of the lateral hypothalamus (LH) produce aphagia. Several previous studies have reported that lateral hypothalamus damage produces food aversion in addition to aphagia. However, damage to other regions near the LH also produce aphagia and enhanced aversion. The purpose of this study was to resolve where the site or sites for aversion-inducing lesions is/are located. Small, bilateral excitotoxin lesions (QUIN, 10 [mu]g in 1 [mu]l or IBO, 15 [mu]g in 1 [mu]l) or bilateral sham injections of vehicle were made into the globus pallidus (GP), the ventral pallidum/substantia innominata (VP/SI) or the lateral hypothalamus (LH). Affective reactions to taste were elicited by infusing sucrose solutions (1 M) into the mouth via chronic oral cannulae. The number of aversive responses (gapes, chin-rubbing, head-shaking and forelimb flails) emitted was tallied. Individual lesions were mapped and a single `necessary and sufficient' site for damage-induced aversion was identified (the area of overlapping damage common to all rats that showed enhanced aversive reactions). To identify the lesions, two lesion-mapping techniques were used: (1) a conventional neuron-counting procedure in which an attempt is made to count all neurons within a brain region, and (2) a new modified `fractionator' procedure consisting of exhaustive 400 x magnification counts at point locations within a brain region. Results indicated that aversive reactions to food are enhanced only following bilateral neuron loss (&gt;70%) from the caudal ventromedial VP/SI alone. This shared site has a lateral diameter of 1.0 mm, a dorsoventral diameter of 0.5 mm and a rostrocaudal diameter of 1.0 mm. Damage restricted to the LH never produced enhanced aversion even when it produced aphagia. The crucial region for aversion is located ventral and medial to the globus pallidus and dorsal and lateral to the lateral hypothalamus. en_US
dc.format.extent 1012642 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Elsevier en_US
dc.title Where does damage lead to enhanced food aversion: the ventral pallidum/substantia innominata or lateral hypothalamus? en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Public Health en_US
dc.subject.hlbsecondlevel Neurosciences en_US
dc.subject.hlbsecondlevel Molecular, Cellular and Developmental Biology en_US
dc.subject.hlbtoplevel Science en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Psychology, The University of Michigan, Ann Arbor, MI 48104-1687, USA en_US
dc.contributor.affiliationum Department of Psychology, The University of Michigan, Ann Arbor, MI 48104-1687, USA en_US
dc.identifier.pmid 8252379 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/30517/1/0000147.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1016/0006-8993(93)90053-P en_US
dc.identifier.source Brain Research en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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