Effect of ramipril on [alpha]-adrenoceptor-mediated oscillatory contractions in tail artery of hypertensive rats
dc.contributor.author | Watts, Stephanie W. | en_US |
dc.contributor.author | Traub, Oren | en_US |
dc.contributor.author | Lamb, Fred S. | en_US |
dc.contributor.author | Myers, J. Hurley | en_US |
dc.contributor.author | Webb, R. Clinton | en_US |
dc.date.accessioned | 2006-04-10T15:33:22Z | |
dc.date.available | 2006-04-10T15:33:22Z | |
dc.date.issued | 1993-10-05 | en_US |
dc.identifier.citation | Watts, Stephanie W., Traub, Oren, Lamb, Fred S., Myers, J. Hurley, Webb, R. Clinton (1993/10/05)."Effect of ramipril on [alpha]-adrenoceptor-mediated oscillatory contractions in tail artery of hypertensive rats." European Journal of Pharmacology 242(3): 245-253. <http://hdl.handle.net/2027.42/30518> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1J-479DTDK-9N/2/a33df30f933349d6503377bb095f14d3 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30518 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8281989&dopt=citation | en_US |
dc.description.abstract | Recent studies indicate that norepinephrine-induced contractile oscillations in the tail artery from stroke-prone spontaneously hypertensive rats (SHRSP) may be a vascular phenomenon independent of blood pressure level. The objectives of this study were: (1) to characterize pharmacologically the [alpha]-adrenoceptor mediating norepinephrine-induced oscillations in tail artery; and (2) to investigate the relationship between blood pressure level, altered by treatments with hydralazine/hydrochlorothiazide or the angiotensin converting enzyme inhibitor ramipril, and the observation of norepinephrine-induced oscillations in tail artery. The [alpha]2-adrenoceptor agonists clonidine and guanabenz potently stimulated oscillatory contractions in the tail artery while the [alpha]1-adrenoceptor agonists phenylephrine and methoxamine were considerably less potent. Yohimbine, an [alpha]2-adrenoceptor antagonist, but not the [alpha]1-adrenoceptor antagonist prazosin demonstrated high affinity for the receptor mediating norepinephrine-induced oscillatory contractions. These results support the hypothesis that norepinephrine-induced oscillatory contractions in the tail artery from SHRSP occur primarily through stimulation of [alpha]2-adrenoceptors. Ramipril lowered blood pressure in SHRSP after 4 weeks of treatment during 6-10 weeks of life but did not alter the ability of the [alpha]2-adrenoceptor agonist clonidine (10-5 M) to induce contractile oscillations in tail arteries from SHRSP, indicating these oscillations are not a secondary effect of high blood pressure. These studies suggest that norepinephrine-induced oscillations in tail artery from SHRSP may be a vascular trait separate and distinct from blood pressure level and angiotensin II expression early in life. | en_US |
dc.format.extent | 867496 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Effect of ramipril on [alpha]-adrenoceptor-mediated oscillatory contractions in tail artery of hypertensive rats | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Physiology, The University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Physiology, The University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Physiology, The University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Physiology, The University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Physiology, The University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 8281989 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30518/1/0000149.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0014-2999(93)90248-G | en_US |
dc.identifier.source | European Journal of Pharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.