Gabapentin actions on ligand- and voltage-gated responses in cultured rodent neurons
dc.contributor.author | Rock, David M. | en_US |
dc.contributor.author | Kelly, Kevin M. | en_US |
dc.contributor.author | Macdonald, Robert L. | en_US |
dc.date.accessioned | 2006-04-10T15:33:51Z | |
dc.date.available | 2006-04-10T15:33:51Z | |
dc.date.issued | 1993-10 | en_US |
dc.identifier.citation | Rock, David M., Kelly, Kevin M., Macdonald, Robert L. (1993/10)."Gabapentin actions on ligand- and voltage-gated responses in cultured rodent neurons." Epilepsy Research 16(2): 89-98. <http://hdl.handle.net/2027.42/30530> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T34-4861SRC-1V/2/59102c7e64cb48b456eaca80fa120bf0 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30530 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7505742&dopt=citation | en_US |
dc.description.abstract | Gabapentin (GBP) is a cyclic [gamma]-aminobutyric acid (GABA) analog and investigational antiepileptic drug which is effective in the treatment of a variety of human and experimental seizures. GBP's antiepileptic mechanism of action is not known. The present studies tested for effects of GBP on inhibitory (GABA and glycine) and excitatory ( (NMDA) and non-NMDA) amino acid neurotransmitter receptors, on repetitive firing of sodium (Na+) action potentials, and on voltage-dependent calcium (Ca2+) channel currents in cultured rodent neurons using intracellular, whole cell, or single channel recording techniques. GBP did not have a significant effect in any experiment when tested at or above concentrations that are therapeutic in humans except for a variable enhancement of NMDA-evoked depolarizations. These results suggest that the antiepileptic activity of GBP is not due to direct effects at receptors for inhibitory or excitatory amino acids or on voltage-dependent Na+ or Ca2+ channels. | en_US |
dc.format.extent | 966341 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Gabapentin actions on ligand- and voltage-gated responses in cultured rodent neurons | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Kinesiology and Sports | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Pharmacology Department, Parke-Davis Research, 2800 Plymouth Road, Ann Arbor, MI 48106-1047, USA; Neuroscience Program, University of Michigan Medical Center, Ann Arbor, MI 48109, USA. | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA; Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA. | en_US |
dc.identifier.pmid | 7505742 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30530/1/0000162.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0920-1211(93)90023-Z | en_US |
dc.identifier.source | Epilepsy Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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