Smooth Muscle Myosin Heavy Chain Locus (MYH11) Maps to 16p13.13-p13.12 and Establishes a New Region of Conserved Synteny between Human 16p and Mouse 16
dc.contributor.author | Deng, Zuoming | en_US |
dc.contributor.author | Liu, Pu | en_US |
dc.contributor.author | Marlton, Paula | en_US |
dc.contributor.author | Claxton, David F. | en_US |
dc.contributor.author | Lane, Sharon | en_US |
dc.contributor.author | Callen, David F. | en_US |
dc.contributor.author | Collins, Francis S. | en_US |
dc.contributor.author | Siciliano, Michael J. | en_US |
dc.date.accessioned | 2006-04-10T15:34:08Z | |
dc.date.available | 2006-04-10T15:34:08Z | |
dc.date.issued | 1993-10 | en_US |
dc.identifier.citation | Deng, Zuoming, Liu, Pu, Marlton, Paula, Claxton, David F., Lane, Sharon, Callen, David F., Collins, Francis S., Siciliano, Michael J. (1993/10)."Smooth Muscle Myosin Heavy Chain Locus (MYH11) Maps to 16p13.13-p13.12 and Establishes a New Region of Conserved Synteny between Human 16p and Mouse 16." Genomics 18(1): 156-159. <http://hdl.handle.net/2027.42/30537> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WG1-45PMR53-2T/2/ac6f332ba96983e68b075b23bfbf7f44 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30537 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8276405&dopt=citation | en_US |
dc.description.abstract | The human smooth myosin heavy chain locus (MYH11) was mapped by fluorescence in situ hybridization to the middle of the p arm of chromosome 16 using a genomic cosmid clone containing coding sequences of the gene as probe. Probe from coding sequence, when applied to Southern blots of a panel of hybrids containing different portions of human chromosome 16, localized the gene to 16p13.13-13.12. Coding sequence PCR primers, when used on the DNA from a CHO-mouse hybrid clone mapping panel informative for mouse chromosomes, showed that the gene was located on mouse chromosome 16. These results correct a recent assignment of MYH11 from 16q12.2 to the region of the 16p-arm inversion breakpoint seen in acute myelomonocytic leukemia (AMML) M4Eo and demonstrate that the conflicting data do not result from the presence of additional MYH genes on the q arm of the chromosome. Also, a new region of conserved synteny between human 16p and mouse 16 is established. | en_US |
dc.format.extent | 397989 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Smooth Muscle Myosin Heavy Chain Locus (MYH11) Maps to 16p13.13-p13.12 and Establishes a New Region of Conserved Synteny between Human 16p and Mouse 16 | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109. | en_US |
dc.contributor.affiliationum | Howard Hughes Medical Institute and Departments of Internal Medicine and Medical Genetics, University of Michigan Medical Center, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationother | Department of Molecular Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA. | en_US |
dc.contributor.affiliationother | Department of Hematology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA. | en_US |
dc.contributor.affiliationother | Department of Hematology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA. | en_US |
dc.contributor.affiliationother | Department of Cytogenetics and Molecular Genetics, Adelaide Children's Hospital, North Adelaide, Australia | en_US |
dc.contributor.affiliationother | Department of Cytogenetics and Molecular Genetics, Adelaide Children's Hospital, North Adelaide, Australia | en_US |
dc.contributor.affiliationother | Department of Molecular Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA. | en_US |
dc.identifier.pmid | 8276405 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30537/1/0000170.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1006/geno.1993.1443 | en_US |
dc.identifier.source | Genomics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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