Infectivity of a glucan synthesis-defective mutant of Streptococcus gordonii (Challis) in a rat endocarditis model
dc.contributor.author | Wells, Virginia D. | en_US |
dc.contributor.author | Munro, Cindy L. | en_US |
dc.contributor.author | Sulavik, Mark C. | en_US |
dc.contributor.author | Clewell, Don B. | en_US |
dc.contributor.author | Macrina, Francis L. | en_US |
dc.date.accessioned | 2006-04-10T15:35:37Z | |
dc.date.available | 2006-04-10T15:35:37Z | |
dc.date.issued | 1993-09-15 | en_US |
dc.identifier.citation | Wells, Virginia D., Munro, Cindy L., Sulavik, Mark C., Clewell, Don B., Macrina, Francis L. (1993/09/15)."Infectivity of a glucan synthesis-defective mutant of Streptococcus gordonii (Challis) in a rat endocarditis model." FEMS Microbiology Letters 112(3): 301-305. <http://hdl.handle.net/2027.42/30573> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T2W-476HNRF-70/2/4be26516ad38c28b3e7de93838e50701 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30573 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8224794&dopt=citation | en_US |
dc.description.abstract | Streptococcus gordonii, a member of the human indigenous oral microflora, colonizes smooth tooth surfaces and contributes to dental plaque formation. Although it is not recognized as being a cariogenic pathogen, it may cause endocarditis following invasion of the bloodstream. Using allelic exchange mutagenesis, we have constructed a mutant of S. gordonii (Challis) which is defective in its single functional glucosyltransferase gene and, hence, is unable to synthesize glucan exopolymers from sucrose. When examined in a rat endocarditis model, the sucrose-grown mutant did not differ significantly from S. gordonii wild-type, suggesting that glucan polymers did not contribute to infectivity. This result was in striking contrast to that previously observed with a polymer-defective S. mutans mutant. | en_US |
dc.format.extent | 381161 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Infectivity of a glucan synthesis-defective mutant of Streptococcus gordonii (Challis) in a rat endocarditis model | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Microbiology and Immunology, The University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, Michigan, USA; Department of Microbiology and Immunology, The University of Michigan, Ann Arbor, Michigan, USA. | en_US |
dc.contributor.affiliationother | Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA | en_US |
dc.contributor.affiliationother | Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA | en_US |
dc.contributor.affiliationother | Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA | en_US |
dc.identifier.pmid | 8224794 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30573/1/0000208.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0378-1097(93)90616-A | en_US |
dc.identifier.source | FEMS Microbiology Letters | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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