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Effects of cocaine on dopamine receptor gene expression: A study in the postmortem human brain
dc.contributor.authorMeador-Woodruff, James H.en_US
dc.contributor.authorLittle, Karley Y.en_US
dc.contributor.authorDamask, Scott P.en_US
dc.contributor.authorMansour, Alfreden_US
dc.contributor.authorWatson, Stanley J.en_US
dc.date.accessioned2006-04-10T15:35:39Z
dc.date.available2006-04-10T15:35:39Z
dc.date.issued1993-09-15en_US
dc.identifier.citationMeador-Woodruff, James H., Little, Karley Y., Damask, Scott P., Mansour, Alfred, Watson, Stanley J. (1993/09/15)."Effects of cocaine on dopamine receptor gene expression: A study in the postmortem human brain." Biological Psychiatry 34(6): 348-355. <http://hdl.handle.net/2027.42/30574>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T4S-484N83H-ST/2/be7e5a9edf8faa523366c8df8e2ebaaden_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30574
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8218601&dopt=citationen_US
dc.description.abstractThe effects of chronic cocaine exposure on dopamine D1 and D2 receptor gene expression in the human brain were studied in postmortem samples from chronic cocaine abusing and matched control subjects. Using in situ hybridization and receptor autoradiography to examine messenger ribonucleic acid (RNA) and binding sites, respectively, neither D1 nor D2 receptor expression was found to be changed in the nucleus accumbens, caudate, putamen, or substantia nigra of the cocaine-exposed subjects. Although chronic cocaine exposure can produce alterations in dopaminergic neurotransmission, sustained compensatory changes in dopamine receptor expression do not appear to occur in the human.en_US
dc.format.extent775929 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleEffects of cocaine on dopamine receptor gene expression: A study in the postmortem human brainen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMental Health Research Institute and Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumMental Health Research Institute and Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumMental Health Research Institute and Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumMental Health Research Institute and Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationotherDepartment of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USAen_US
dc.identifier.pmid8218601en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30574/1/0000209.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-3223(93)90178-Gen_US
dc.identifier.sourceBiological Psychiatryen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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