Localization of preproenkephalin mRNA-expressing cells in rat auditory brainstem with in situ hybridization
dc.contributor.author | Hoffman, Douglas W. | en_US |
dc.contributor.author | Hochreiter, Jill S. | en_US |
dc.contributor.author | Landry, Douglas R. | en_US |
dc.contributor.author | Brimijoin, Megan R. | en_US |
dc.contributor.author | Treadwell, Melinda D. | en_US |
dc.contributor.author | Gardner, Paul D. | en_US |
dc.contributor.author | Altschuler, Richard A. | en_US |
dc.date.accessioned | 2006-04-10T15:35:49Z | |
dc.date.available | 2006-04-10T15:35:49Z | |
dc.date.issued | 1993-09 | en_US |
dc.identifier.citation | Hoffman, Douglas W., Hochreiter, Jill S., Landry, Douglas R., Brimijoin, Megan R., Treadwell, Melinda D., Gardner, Paul D., Altschuler, Richard A. (1993/09)."Localization of preproenkephalin mRNA-expressing cells in rat auditory brainstem with in situ hybridization." Hearing Research 69(1-2): 1-9. <http://hdl.handle.net/2027.42/30578> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T73-487CV3T-24/2/f011ab99012988fd91240af29a149140 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30578 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8226328&dopt=citation | en_US |
dc.description.abstract | Hair cells and auditory nerve dendrites in the inner ear are innervated by pontine neurons that have been demonstrated by immunochemical techniques to contain several neurotransmitters, including acetylcholine and the opioid peptide enkephalins and dynorphins. The functions of these nerve fibers are not known, but may involve modifying auditory sensitivity to low intensity stimuli. In the guinea pig the opioid pathways originate in the lateral superior olivary region. A recent study in the gerbil has reported cells expressing preproenkephalin mRNA present only in the ventral nucleus of the trapezoid body, and not in the superior olivary region. In the present study, a non-radioisotopically labeled in situ hybridization method was used to identify cells expressing mRNA coding for preproenkephalin in rat pontine neurons, specifically in the ventral nucleus of the trapezoid body. These cells may represent an enkephalin-containing medial olivocochlear system in the rat, the origin of the lateral system in the rat that differs markedly from the better-studied guinea pig and cat, or a non-olivocochlear enkephalin-containing system. | en_US |
dc.format.extent | 1564769 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Localization of preproenkephalin mRNA-expressing cells in rat auditory brainstem with in situ hybridization | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire, USA; Department of Psychiatry, Dartmouth Medical School, Hanover, New Hampshire, USA. | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Dartmouth Medical School, Hanover, New Hampshire, USA | en_US |
dc.contributor.affiliationother | Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire, USA; Department of Psychiatry, Dartmouth Medical School, Hanover, New Hampshire, USA. | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Dartmouth Medical School, Hanover, New Hampshire, USA | en_US |
dc.contributor.affiliationother | Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire, USA | en_US |
dc.contributor.affiliationother | Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire, USA | en_US |
dc.identifier.pmid | 8226328 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30578/1/0000213.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0378-5955(93)90087-H | en_US |
dc.identifier.source | Hearing Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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