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A Radiation Hybrid Map of the BRCA1 Region of Chromosome 17q12-q21
dc.contributor.authorAbel, Kenneth J.en_US
dc.contributor.authorBoehnke, Michaelen_US
dc.contributor.authorPrahalad, Muralien_US
dc.contributor.authorHo, Peggy P.en_US
dc.contributor.authorFlejter, Wendy L.en_US
dc.contributor.authorWatkins, Melanieen_US
dc.contributor.authorVanderStoep, Jillen_US
dc.contributor.authorChandrasekharappa, Settara C.en_US
dc.contributor.authorCollins, Francis S.en_US
dc.contributor.authorGlover, Thomas W.en_US
dc.contributor.authorWeber, Barbara L.en_US
dc.date.accessioned2006-04-10T15:37:26Z
dc.date.available2006-04-10T15:37:26Z
dc.date.issued1993-09en_US
dc.identifier.citationAbel, Kenneth J., Boehnke, Michael, Prahalad, Murali, Ho, Peggy, Flejter, Wendy L., Watkins, Melanie, VanderStoep, Jill, Chandrasekharappa, Settara C., Collins, Francis S., Glover, Thomas W., Weber, Barbara L. (1993/09)."A Radiation Hybrid Map of the BRCA1 Region of Chromosome 17q12-q21." Genomics 17(3): 632-641. <http://hdl.handle.net/2027.42/30614>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WG1-45PMSYS-S0/2/128adc2278358885818479b4640667bden_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30614
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8244380&dopt=citationen_US
dc.description.abstractThe chromosomal region 17q12-q21 contains a gene (BRCA1) conferring susceptibility to early-onset familial breast and ovarian cancer. An 8000-rad radiation-reduced hybrid (RH) panel was constructed to provide a resource for long-range mapping of this region. A large fraction of the hybrids (~90%) retained detectable human chromosome 17 sequences. The complete panel of 76 hybrids was scored for the presence or absence of 22 markers from this chromosomal region, including 14 cloned genes, seven microsatellite repeats, and one anonymous DNA segment. Statistical analysis of the marker retention data employing multipoint methods provided both comprehensive and framework maps of this chromosomal region, including distance estimates between adjacent markers. The comprehensive RH map includes 17 loci and spans 179 cRays(8000). Likelihood rations of at least 1000:1 support the 10-locus framework order: cen-D17S250-ERBB2-(THRIA1, TOP2A)-D17S855-PPY-DI7S190-MTBT1-GP3A-BTR-D17S588-tel. The order obtained from RH mapping, when used in conjunction with other methods, will be useful in linkage analysis of breast cancer families and will facilitate the development of a physical map of this region.en_US
dc.format.extent613503 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleA Radiation Hybrid Map of the BRCA1 Region of Chromosome 17q12-q21en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Howard Hughes Medical Institute, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationumDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA; Michigan Human Genome Center, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationumDepartments of Human Genetics and Pediatrics, University of Michigan, Ann Arbor, MI, USA; Michigan Human Genome Center, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartments of Human Genetics and Pediatrics, University of Michigan, Ann Arbor, MI, USA; Michigan Human Genome Center, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, USA; Michigan Human Genome Center, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationumDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USA; Michigan Human Genome Center, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationumDepartments of Internal Medicine and Human Genetics, University of Michigan, Ann Arbor, MI, USA; Michigan Human Genome Center, Ann Arbor, MI, USA; Howard Hughes Medical Institute, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationumDepartments of Human Genetics and Pediatrics, University of Michigan, Ann Arbor, MI, USA; Michigan Human Genome Center, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USAen_US
dc.identifier.pmid8244380en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30614/1/0000254.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1006/geno.1993.1383en_US
dc.identifier.sourceGenomicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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