Long-term endocrine function in hypercholesterolemic patients treated with pravastatin, a new 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor,
dc.contributor.author | Dobs, Adrian S. | en_US |
dc.contributor.author | Sarma, P. Sankara | en_US |
dc.contributor.author | Schteingart, David E. | en_US |
dc.date.accessioned | 2006-04-10T15:37:49Z | |
dc.date.available | 2006-04-10T15:37:49Z | |
dc.date.issued | 1993-09 | en_US |
dc.identifier.citation | Dobs, Adrian S., Sarma, P. Sankara, Schteingart, David (1993/09)."Long-term endocrine function in hypercholesterolemic patients treated with pravastatin, a new 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor,." Metabolism 42(9): 1146-1152. <http://hdl.handle.net/2027.42/30622> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WN4-4C35P4N-F/2/3c1e1a1a1a846829763bc1723e57d0e2 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30622 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8412767&dopt=citation | en_US |
dc.description.abstract | Steroid hormone production within the gonads and adrenals requires a continuous supply of cholesterol derived from de novo synthesis within the gland and from uptake of circulating plasma lipoproteins. Steroid hormone secretion was prospectively studied over 24 months in 64 hypercholesterolemic subjects (group I, aged 52 +/- 1 years [mean +/- SEM], 61% male) participating in a randomized double-blind clinical trial of pravastatin (20 to 80 mg daily), a new 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, compared with patients taking cholestyramine or other lipid-lowering drugs (group II). Attempts were made in both groups to maintain serum low-density lipoprotein cholesterol (LDL-C) levels between the 25th and 50th percentile for age and gender. At 24 months, serum LDL-C level decreased by 42% +/- 3% in group I and 44% +/- 1% in group II (P v baseline, NS between groups). Basal secretion of cortisol, aldosterone, and dehydroepiandrostenedione sulfate (DHEA-S) was maintained throughout the study. However, the serum DHEA-S secretory response to Cortrosyn (Organon, West Orange, NJ) diminished in both treatment groups at 6 and 12 months (P P < .05). In conclusion, pravastatin had no significant effect on steroid metabolism. Changes noted in DHEA-S were not specific for pravastatin, suggesting that this impairment is related to lipid-lowering effects. | en_US |
dc.format.extent | 786932 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Long-term endocrine function in hypercholesterolemic patients treated with pravastatin, a new 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA. | en_US |
dc.contributor.affiliationum | Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA; Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. | en_US |
dc.contributor.affiliationum | Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA; Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. | en_US |
dc.identifier.pmid | 8412767 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30622/1/0000263.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0026-0495(93)90272-P | en_US |
dc.identifier.source | Metabolism | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.