bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
dc.contributor.author | Boise, Lawrence H. | en_US |
dc.contributor.author | Gonzalez-Garcia, Maribel | en_US |
dc.contributor.author | Postema, Christina E. | en_US |
dc.contributor.author | Ding, Liyun | en_US |
dc.contributor.author | Lindsten, Tullia | en_US |
dc.contributor.author | Turka, Laurence A. | en_US |
dc.contributor.author | Mao, Xiaohong | en_US |
dc.contributor.author | Nunez, Gabriel | en_US |
dc.contributor.author | Thompson, Craig B. | en_US |
dc.date.accessioned | 2006-04-10T15:38:09Z | |
dc.date.available | 2006-04-10T15:38:09Z | |
dc.date.issued | 1993-08-27 | en_US |
dc.identifier.citation | Boise, Lawrence H., Gonzalez-Garcia, Maribel, Postema, Christina E., Ding, Liyun, Lindsten, Tullia, Turka, Laurence A., Mao, Xiaohong, Nunez, Gabriel, Thompson, Craig B. (1993/08/27)."bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death." Cell 74(4): 597-608. <http://hdl.handle.net/2027.42/30629> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WSN-4C6BNG6-7J/2/d55e0f3471dd8e68952d1f182319f5f0 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30629 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8358789&dopt=citation | en_US |
dc.description.abstract | We report the isolation of bcl-x, a bcl-2-related gene that can function as a bcl-2-independent regulator of programed cell death (apoptosis). Alternative splicing results in two distinct bcl-x mRNAs. The protein product of the larger mRNA, bcl-xL, is similar in size and predicted structure to Bcl-2. When stably transfected into an IL-3-dependent cell line, bcl-xL inhibits cell death upon growth factor withdrawal at least as well as bcl-2. Surprisingly, the second mRNA species, bcl-xS, encodes a protein that inhibits the ability of bcl-2 to enhance the survival of growth factor-deprived cells. In vivo, bcl-xS mRNA is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, bcl-xL is found in tissues containing long-lived postmitotic cells, such as adult brain. Together these data suggest that bcl-x plays an important role in both positive and negative regulation of programed cell death. | en_US |
dc.format.extent | 2186793 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pathology University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Medicine University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Department of Medicine University of Michigan Medical School, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationother | Departments of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA | en_US |
dc.contributor.affiliationother | Departments of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA | en_US |
dc.contributor.affiliationother | Departments of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA | en_US |
dc.contributor.affiliationother | Departments of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA | en_US |
dc.contributor.affiliationother | Departments of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA | en_US |
dc.identifier.pmid | 8358789 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30629/1/0000270.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0092-8674(93)90508-N | en_US |
dc.identifier.source | Cell | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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