Alkylation of human albumin by the antimalarial artemisinin
dc.contributor.author | Ying-Zi Yang, | en_US |
dc.contributor.author | Asawamahasakda, Wanida | en_US |
dc.contributor.author | Meshnick, Steven R. | en_US |
dc.date.accessioned | 2006-04-10T15:40:17Z | |
dc.date.available | 2006-04-10T15:40:17Z | |
dc.date.issued | 1993-07-20 | en_US |
dc.identifier.citation | Ying-Zi Yang, , Asawamahasakda, Wanida, Meshnick, Steven R. (1993/07/20)."Alkylation of human albumin by the antimalarial artemisinin." Biochemical Pharmacology 46(2): 336-339. <http://hdl.handle.net/2027.42/30679> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T4P-4755BJG-73/2/6eaf53c71f1c3d06d88f7c415bac5db4 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30679 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8347159&dopt=citation | en_US |
dc.description.abstract | The interaction between artemisinin and human serum was studied in vitro using [3H]-dihydroartemisinin and [14C]artemisinin. Approximately 20% of added drug was covalently bound to albumin in 24 hr. The results of electrospray ionization mass spectra showed that albumin had an Mr value of 66,745 +/- 35 and the drug-bound albumin had an Mr of 67,223 +/- 34. The binding was blocked 15 and 58% by iodoacetamide (IA) and N-ethylmaleimide, respectively, and 80% by the combination of IA and succinic anhydride. Hemin and Fe2+ increased the binding by 40 and 10%, respectively, whereas deferoxamine inhibited the binding by 10%. Therefore, we conclude that the binding between artemisinin and albumin probably involves thiol and amino groups via both iron-dependent and -independent reactions. | en_US |
dc.format.extent | 425160 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Alkylation of human albumin by the antimalarial artemisinin | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 8347159 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30679/1/0000323.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-2952(93)90425-V | en_US |
dc.identifier.source | Biochemical Pharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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