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Phosphoenolpyruvate Carboxykinase (GTP): Characterization of the Human PCK1 Gene and Localization Distal to MODY on Chromosome 20
dc.contributor.authorTing, Chao-Nanen_US
dc.contributor.authorBurgess, Daniel L.en_US
dc.contributor.authorChamberlain, Jeffrey S.en_US
dc.contributor.authorKeith, Tim P.en_US
dc.contributor.authorFalls, Kathleenen_US
dc.contributor.authorMeisler, Miriam H.en_US
dc.date.accessioned2006-05-10T15:41:24Z
dc.date.available2006-05-10T15:41:24Z
dc.date.issued1993-06en_US
dc.identifier.citationTing, Chao-Nan, Burgess, Daniel L., Chamberlain, Jeffrey S., Keith, Tim P., Falls, Kathleen, Meisler, Miriam H. (1993/06)."Phosphoenolpyruvate Carboxykinase (GTP): Characterization of the Human PCK1 Gene and Localization Distal to MODY on Chromosome 20." Genomics 16(3): 698-706. <http://hdl.handle.net/2027.42/30779>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WG1-45PMT6F-WN/2/1f2318d183f7f5014da4cb2c1e56cf4cen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30779
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8325643&dopt=citationen_US
dc.description.abstractThe human PCK1 gene encoding phosphoenolpyruvate carboxykinase (GTP) (PEPCK) was isolated and sequenced. There is 91% amino acid sequence identity (567/622 residues) between the human and the rat proteins, with conservation of intron/exon borders. A polymorphic dinucleotide microsatellite with the structure (CA)16(TA)5(CA) was identified in the 3' untranslated region of the cloned human PCK1 gene. This highly informative genetic marker has an estimated PIC value of 0.79 and heterozygosity of 0.81. Analysis of the RW pedigree demonstrated recombination between PCK1 and the MODY gene on chromosome 20. Multipoint linkage analysis of the reference pedigrees of the Centre d'Etude du Polymorphisme Humain localized PCK1 on the genetic map of chromosome 20 at a position distal to markers that are closely linked to MODY. PCK1 is part of a conserved linkage group on mouse Chromosome 2 with identical gene order but expanded length in the human genome.en_US
dc.format.extent9 bytes
dc.format.extent3118 bytes
dc.format.extent579282 bytes
dc.format.mimetypetext/plain
dc.format.mimetypetext/plain
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.titlePhosphoenolpyruvate Carboxykinase (GTP): Characterization of the Human PCK1 Gene and Localization Distal to MODY on Chromosome 20en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumSection of Pediatric Surgery, Department of Surgery, University, of Michigan, Ann Arbor, Michigan 48109-0245, USA.en_US
dc.contributor.affiliationumSection of Pediatric Surgery, Department of Surgery, University, of Michigan, Ann Arbor, Michigan 48109-0245, USA.en_US
dc.contributor.affiliationumSection of Pediatric Surgery, Department of Surgery, University, of Michigan, Ann Arbor, Michigan 48109-0245, USA.en_US
dc.contributor.affiliationumSection of Pediatric Surgery, Department of Surgery, University, of Michigan, Ann Arbor, Michigan 48109-0245, USA.en_US
dc.contributor.affiliationotherDepartment of Surgery, Duke University, Durham, North Carolina 27706, USA.en_US
dc.contributor.affiliationotherDepartment of Surgery, Duke University, Durham, North Carolina 27706, USA.en_US
dc.identifier.pmid8325643en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30779/3/0000430.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1006/geno.1993.1250en_US
dc.identifier.sourceGenomicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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