4-Aminopyridine reduces chorda tympani nerve taste responses to potassium and alkali salts in rat
dc.contributor.author | Kim, Miwon | en_US |
dc.contributor.author | Mistretta, Charlotte M. | en_US |
dc.date.accessioned | 2006-04-10T15:45:04Z | |
dc.date.available | 2006-04-10T15:45:04Z | |
dc.date.issued | 1993-05-28 | en_US |
dc.identifier.citation | Kim, Miwon, Mistretta, Charlotte M. (1993/05/28)."4-Aminopyridine reduces chorda tympani nerve taste responses to potassium and alkali salts in rat." Brain Research 612(1-2): 96-103. <http://hdl.handle.net/2027.42/30786> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-482YW2H-5W/2/73b69956a0613c146503a4e26afda21f | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30786 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8330218&dopt=citation | en_US |
dc.description.abstract | To study the potential role of potassium channels in the taste response to potassium salts, we applied 4-aminopyridine (4-AP) to the anterior rat tongue and recorded chorda tympani nerve taste responses to chemical stimuli. 4-aminopyridine is a pharmacological blocker that reduces potassium conductance through potassium channels in nerve and muscle. Summated neural responses to stimuli dissolved in water and in 4-AP were compared. Chemical stimuli included concentration ranges of KCl, KBr, KH2PO4, CsCl, RbCl, NH4Cl, NaCl and sucrose. The blocker reduced chorda tympani responses to KCl and other potassium salts, from 0.025 to 0.25 M. Responses to ammonium, rubidium and cesium salts also were reduced, in order of effectiveness that would be predicted from known ion selectivity properties of potassium channels. Responses to NaCl and sucrose were not reduced. Other channel blockers, including tetraethylammonium chloride (TEA), BaCl2 and quinidine, did not reduce the response to KCl. These are the first detailed reports of effects of potassium channel blockers on the peripheral, neural taste response. The results are consistent with a role for potassium channels in apical taste bud cell membranes in transduction for potassium salts. | en_US |
dc.format.extent | 683391 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | 4-Aminopyridine reduces chorda tympani nerve taste responses to potassium and alkali salts in rat | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biologic and Materials Sciences, School of Dentistry and Center for Human Growth and Development, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Biologic and Materials Sciences, School of Dentistry and Center for Human Growth and Development, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 8330218 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30786/1/0000439.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(93)91648-C | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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