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Pyrroloquinoline Quinone Acts with Flavin Reductase to Reduce Ferryl Myoglobin in Vitro and Protects Isolated Heart from Reoxygenation Injury

dc.contributor.authorXu F. ,en_US
dc.contributor.authorMack C. P. ,en_US
dc.contributor.authorQuandt K. S. ,en_US
dc.contributor.authorShlafer M. ,en_US
dc.contributor.authorMassey V. ,en_US
dc.contributor.authorHultquist D. E. ,en_US
dc.date.accessioned2006-04-10T15:45:08Z
dc.date.available2006-04-10T15:45:08Z
dc.date.issued1993-05-28en_US
dc.identifier.citationXu F., , Mack C. P., , Quandt K. S., , Shlafer M., , Massey V., , Hultquist D. E., (1993/05/28)."Pyrroloquinoline Quinone Acts with Flavin Reductase to Reduce Ferryl Myoglobin in Vitro and Protects Isolated Heart from Reoxygenation Injury." Biochemical and Biophysical Research Communications 193(1): 434-439. <http://hdl.handle.net/2027.42/30787>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-45PTVYJ-1BB/2/7afc82564f18d3a90a7ac3d01983e76ben_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30787
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8389151&dopt=citationen_US
dc.description.abstractPyrroloquinoline quinone has been isolated from bacteria and recently has been detected in mammalian tissues and fluids. We report in vitro studies which show that pyrroloquinoline quinone serves as a high-affinity substrate for an erythrocyte "flavin reductase" and that the pyrroloquinoline quinol generated by this catalysis reacts rapidly with ferryl myoglobin radical. Western blot analysis of rat and rabbit heart homogenates detects a cross-reactive protein which has a molecular weight identical to the erythrocyte reductase from the same species. Low concentrations of pyrroloquinoline quinone protect isolated rabbit heart from reoxygenation injury, serving as an effective tissue-protective agent in this model for cellular oxidative damage. We propose that this tissue protection is due to a pyrroloquinoline quinol-mediated reduction of reactive oxygen species.en_US
dc.format.extent378946 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titlePyrroloquinoline Quinone Acts with Flavin Reductase to Reduce Ferryl Myoglobin in Vitro and Protects Isolated Heart from Reoxygenation Injuryen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USAen_US
dc.identifier.pmid8389151en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30787/1/0000440.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1006/bbrc.1993.1642en_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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