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Nucleosomal organization of telomere-specific chromatin in rat

dc.contributor.authorMakarov, Vladimir L.en_US
dc.contributor.authorLejnine, Sergueien_US
dc.contributor.authorBedoyan, Jirair K.en_US
dc.contributor.authorLangmore, John P.en_US
dc.date.accessioned2006-04-10T15:45:12Z
dc.date.available2006-04-10T15:45:12Z
dc.date.issued1993-05-21en_US
dc.identifier.citationMakarov, Vladimir L., Lejnine, Serguei, Bedoyan, Jirair, Langmore, John P. (1993/05/21)."Nucleosomal organization of telomere-specific chromatin in rat." Cell 73(4): 775-787. <http://hdl.handle.net/2027.42/30788>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WSN-4C6BNPB-CX/2/46bae0ba7b3996688e8ac8794813a9b7en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30788
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8500170&dopt=citationen_US
dc.description.abstractRat liver interphase chromosomes have telomeres 20-100 kb in length. Micrococcal nuclease digestion of nuclei cleaves telomeres with a uniform 157 bp periodicity, producing soluble particles that sediment in sucrose gradients exactly like oligonucleosomes. The monomeric telomere particles comigrate with nucleosome core particles on nucleoprotein and DNA gels but do not bind H1. DNAase I cleaves telomere nucleoprotein into a series of bands spaced by about 10.4 bp and with the same intensity distribution as bands from bulk nucleosomes. Removal of H1 from chromatin alters the sedimentation properties of telomeres in parallel with bulk chromatin. Thus, telomeres of mammals are constructed of closely spaced nucleosomes, in contrast with the telomeres of lower eukaryotes, which show no evidence of nucleosomal structure.en_US
dc.format.extent2420778 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleNucleosomal organization of telomere-specific chromatin in raten_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumBiophysics Research Division The University of Michigan, Ann Arbor, Michigan 48109-2099, USAen_US
dc.contributor.affiliationumBiophysics Research Division The University of Michigan, Ann Arbor, Michigan 48109-2099, USAen_US
dc.contributor.affiliationumDepartment of Biological Sciences The University of Michigan, Ann Arbor, Michigan 48109-2099, USA; Biophysics Research Division The University of Michigan, Ann Arbor, Michigan 48109-2099, USA.en_US
dc.contributor.affiliationumGraduate Program in Cellular and Molecular Biology The University of Michigan, Ann Arbor, Michigan 48109-2099, USA; Biophysics Research Division The University of Michigan, Ann Arbor, Michigan 48109-2099, USA.en_US
dc.identifier.pmid8500170en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30788/1/0000442.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0092-8674(93)90256-Pen_US
dc.identifier.sourceCellen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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