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Affinity of the antiviral enantiomers of oxathiolane cytosine nucleosides for human 2'-deoxycytidine kinase
dc.contributor.authorShewach, Donna S.en_US
dc.contributor.authorLiotta, Dennis C.en_US
dc.contributor.authorSchinazi, Raymond F.en_US
dc.date.accessioned2006-04-10T15:47:50Z
dc.date.available2006-04-10T15:47:50Z
dc.date.issued1993-04-06en_US
dc.identifier.citationShewach, Donna S., Liotta, Dennis C., Schinazi, Raymond F. (1993/04/06)."Affinity of the antiviral enantiomers of oxathiolane cytosine nucleosides for human 2'-deoxycytidine kinase." Biochemical Pharmacology 45(7): 1540-1543. <http://hdl.handle.net/2027.42/30848>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T4P-477GNXT-2FR/2/7862e501e363aa654149007338ea3a6cen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30848
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8385948&dopt=citationen_US
dc.description.abstractThe two enantiomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) and their 5-fluoro analogs (FTC) were found to be good substrates for human 2'-deoxycytidine kinase with Km values in the 5.7 to 42.1 [mu]M range. The affinity of the (-)-enantiomers was greater than that of the (+)-compounds. These results may explain the greater in vitro antiviral potency against human immunodeficiency virus and hepatitis B virus of the (-)-enantiomers when compared to their (+)-counterparts. The (+)- and (-)-enantiomers of FTC and BCH-189 are the first nucleoside analogs for which we have observed lower apparent kinetic constants for this enzyme in the presence of ATP compared to UTP.en_US
dc.format.extent449951 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleAffinity of the antiviral enantiomers of oxathiolane cytosine nucleosides for human 2'-deoxycytidine kinaseen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationotherLaboratory of Biochemical Pharmacology, Departments of Pediatrics Emory University, Atlanta, GA 30322, U.S.A.en_US
dc.contributor.affiliationotherLaboratory of Biochemical Pharmacology, Departments of Chemistry Emory University, Atlanta, GA 30322, U.S.A.; Veterans Affairs Medical Center, Decatur, GA 30033, U.S.A.en_US
dc.identifier.pmid8385948en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30848/1/0000510.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-2952(93)90058-5en_US
dc.identifier.sourceBiochemical Pharmacologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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