Quantitative structure-activity relationships for the mutagenicity of propylene oxides with Salmonella
dc.contributor.author | Hooberman, Barry H. | en_US |
dc.contributor.author | Chakraborty, Pulak K. | en_US |
dc.contributor.author | Sinsheimer, Joseph E. | en_US |
dc.date.accessioned | 2006-04-10T15:48:02Z | |
dc.date.available | 2006-04-10T15:48:02Z | |
dc.date.issued | 1993-04 | en_US |
dc.identifier.citation | Hooberman, B. H., Chakraborty, P. K., Sinsheimer, J. E. (1993/04)."Quantitative structure-activity relationships for the mutagenicity of propylene oxides with Salmonella." Mutation Research/Genetic Toxicology 299(2): 85-93. <http://hdl.handle.net/2027.42/30853> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B73FB-474X50M-G/2/2eaee7860af72b5167411acde88622e9 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30853 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7680427&dopt=citation | en_US |
dc.description.abstract | A quantitative structure-activity relationship approach was used to investigate the mutagenicity of a series of seventeen-monosubstituted propylene oxides in Salmonella typhimurium strains TA100 and TA1535. Mutagenicity in strain TA100, using a liquid suspension assay, was found to correlate with chemical reactivity, as measured by the rates of reaction with two model bionucleophiles, nicotinamide and 4-(4-nitrobenzyl)pyridine. However, since the reactivity of three of the epoxides did not correlate to their Taft [sigma]* values, as a measure of the electronic effects of substituent groups, neither was their mutagenicity predicted by this substituent constant. The relative mutagenicity for the propylene oxides was different in the liquid suspension assay than that determined by the standard plate incorporation assay and also differed between the two bacterial strains. The assay differences were attributed to epoxide stability. The differences between strains was observed to be due to the response of the error-prone repair system, found only in TA100, to the stronger alkylating agents. | en_US |
dc.format.extent | 622937 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Quantitative structure-activity relationships for the mutagenicity of propylene oxides with Salmonella | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, USA | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, USA | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, USA | en_US |
dc.identifier.pmid | 7680427 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30853/1/0000515.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-1218(93)90085-R | en_US |
dc.identifier.source | Mutation Research/Genetic Toxicology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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