Chronic Intrastriatal Dialytic Administration of Quinolinic Acid Produces Selective Neural Degeneration
dc.contributor.author | Bazzett, Terence J. | en_US |
dc.contributor.author | Becker, Jill B. | en_US |
dc.contributor.author | Kaatz, Kevin W. | en_US |
dc.contributor.author | Albin, Roger L. | en_US |
dc.date.accessioned | 2006-04-10T15:48:39Z | |
dc.date.available | 2006-04-10T15:48:39Z | |
dc.date.issued | 1993-04 | en_US |
dc.identifier.citation | Bazzett, T. J., Becker, J. B., Kaatz, K. W., Albin, R. L. (1993/04)."Chronic Intrastriatal Dialytic Administration of Quinolinic Acid Produces Selective Neural Degeneration." Experimental Neurology 120(2): 177-185. <http://hdl.handle.net/2027.42/30865> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WFG-45PMT1F-N/2/1df4fce426fc324928515fb70a3ad5b6 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30865 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8387931&dopt=citation | en_US |
dc.description.abstract | The excitotoxic hypothesis of Huntington's disease pathogenesis suggests that selective striatal neuronal loss results from excessive activation of striatal excitatory amino acid receptors. Using a microdialysis probe mated to an Alzet 2002 mini-osmotic pump three different concentrations of quinolinic acid or vehicle were administered to the striata of rats over a 3-week period. Animals that received a total of 3.3 [mu]mol of quinolinic acid had significant striatal atrophy that could be attributed to two distinct areas of neuronal loss. First, an area of necrosis surrounding the probe was marked by inflammatory infiltrate and a lack of neurons. In the second region, surrounding the necrotic area, there was a significant reduction in nissl-stained cells, with relative sparing of NADPH-diaphorase-staining neurons. In addition, there was a reduction in cytochrome oxidase staining throughout both of the areas of cell loss. Beyond the area of cell loss, the striatum appeared normal in all respects. The striata of animals that received 880 nmol quinolinic acid appeared identical to those that received vehicle. The striata of animals that received 8.8 [mu]mol quinolinic acid showed severe nonselective atrophy of the striatum and some surrounding structures. We conclude that dialytic delivery of 3.3 [mu]mol quinolinic acid produces an area of neuronal destruction that resembles the selective neuronal loss seen in Huntington's disease. This selective neurodegeneration produced by chronic exposure to quinolinic acid simulates more closely the course of Huntington's disease than previously described methods. | en_US |
dc.format.extent | 871405 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Chronic Intrastriatal Dialytic Administration of Quinolinic Acid Produces Selective Neural Degeneration | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychology, Neuroscience Program, and Reproductive Sciences Program, University of Michigan, Ann Arbor, MI, USA. | en_US |
dc.contributor.affiliationum | Department of Psychology, Neuroscience Program, and Reproductive Sciences Program, University of Michigan, Ann Arbor, MI, USA. | en_US |
dc.contributor.affiliationum | Department of Neurology, and Neuroscience Program, The University of Michigan, Ann Arbor, MI, USA. | en_US |
dc.contributor.affiliationum | Department of Neurology, and Neuroscience Program, The University of Michigan, Ann Arbor, MI, USA. | en_US |
dc.identifier.pmid | 8387931 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30865/1/0000528.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1006/exnr.1993.1053 | en_US |
dc.identifier.source | Experimental Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.