The Genes Encoding Gonadal and Nongonadal Forms of 3[beta]-Hydroxysteroid Dehydrogenase/[Delta]5-[Delta]4 Isomerase Are Closely Linked on Mouse Chromosome 3
dc.contributor.author | Bain, Paul A. | en_US |
dc.contributor.author | Meisler, Miriam H. | en_US |
dc.contributor.author | Taylor, Benjamin A. | en_US |
dc.contributor.author | Payne, Anita H. | en_US |
dc.date.accessioned | 2006-04-10T15:48:51Z | |
dc.date.available | 2006-04-10T15:48:51Z | |
dc.date.issued | 1993-04 | en_US |
dc.identifier.citation | Bain, Paul A., Meisler, Miriam H., Taylor, Benjamin A., Payne, Anita H. (1993/04)."The Genes Encoding Gonadal and Nongonadal Forms of 3[beta]-Hydroxysteroid Dehydrogenase/[Delta]5-[Delta]4 Isomerase Are Closely Linked on Mouse Chromosome 3." Genomics 16(1): 219-223. <http://hdl.handle.net/2027.42/30870> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WG1-45PMT9M-YK/2/c0b90038dc62e073e02f64521e0c61ca | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30870 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8486361&dopt=citation | en_US |
dc.description.abstract | The biosynthesis of steroid hormones in the gonads and adrenal glands requires the activities of the enzyme 3[beta]-hydroxysteroid dehydrogenase/isomerase (3[beta]HSD) which catalyzes the NAD+-dependent dehydrogenation and subsequent [Delta]5 --> [Delta]4 isomerization of [Delta]5-3[beta]-hydroxysteroids to [Delta]4-3-ketosteroids. The mouse expresses four isoforms of 3[beta]HSD. 3[beta]HSD I is expressed in gonads and adrenal glands and appears to be the major steroidogenic form, 3[beta]HSDs II and III are expressed in both liver and kidneys, and 3[beta]HSD IV has been detected only in kidneys. To determine the genetic relationship between the 3[beta]HSD isoforms, we have mapped the chromosomal locations of the four genes by linkage analysis using gene-specific probes derived from the 3' untranslated regions of 3[beta]HSD cDNA clones. The four 3[beta]HSD structural genes (Hsd3b) are closely linked within a segment of chromosome 3 that is conserved on human chromosome 1. The order of markers on Chr 3 surrounding Hsd3b is: centromere-Gba-(4.4 +/- 2.2)-Hsd3b-(3.3 +/- 1.9)-Tshb-(6.7 +/- 2.7)-Amy-1. | en_US |
dc.format.extent | 402383 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The Genes Encoding Gonadal and Nongonadal Forms of 3[beta]-Hydroxysteroid Dehydrogenase/[Delta]5-[Delta]4 Isomerase Are Closely Linked on Mouse Chromosome 3 | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Graduate Program in Cellular and Molecular Biology and Reproductive Sciences Program, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationum | Graduate Program in Cellular and Molecular Biology and Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationum | Graduate Program in Cellular and Molecular Biology, Reproductive Sciences Program, Department of Biological Chemistry and Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationother | The Jackson Laboratory, Bar Harbor, Maine 04609, USA. | en_US |
dc.identifier.pmid | 8486361 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30870/1/0000534.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1006/geno.1993.1162 | en_US |
dc.identifier.source | Genomics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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