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Synthesis of [11C]tetrabenazine, a vesicular monoamine uptake inhibitor, for PET imaging studies
dc.contributor.authorDaSilva, Jean N.en_US
dc.contributor.authorKilbourn, Michael R.en_US
dc.contributor.authorMangner, Thomas J.en_US
dc.date.accessioned2006-04-10T15:49:43Z
dc.date.available2006-04-10T15:49:43Z
dc.date.issued1993-04en_US
dc.identifier.citationDaSilva, Jean N., Kilbourn, Michael R., Mangner, Thomas J. (1993/04)."Synthesis of [11C]tetrabenazine, a vesicular monoamine uptake inhibitor, for PET imaging studies." Applied Radiation and Isotopes 44(4): 673-676. <http://hdl.handle.net/2027.42/30889>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TJ0-46WX5MM-6/2/ce90a311102de1a8bd66c781862d3560en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30889
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8472029&dopt=citationen_US
dc.description.abstractTetrabenazine (TBZ), a high affinity and specific inhibitor of the vesicular monoamine transporter, has been labeled with carbon-11 as a potential probe for in vivo positron emission tomographic imaging of monoaminergic neuronal losses in neurodegenerative diseases. [11C]TBZ was synthesized by O-[11C]methylation of the 9-O-desmethylTBZ using [11C]methyl iodide in the presence of tetrabutyl-ammonium hydroxide. The radiochemical yields were 35-55% (decay corrected) and the synthesis time 32-37 min from EOB. [11C]TBZ was obtained with specific activities of 2000-2500 Ci/mmol (EOS) and radiochemical and chemical purities were &gt;95%. [11C]Tetrabenazine is a promising new radioligand for the in vivo study of monoaminergic neurons using PET.en_US
dc.format.extent402602 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleSynthesis of [11C]tetrabenazine, a vesicular monoamine uptake inhibitor, for PET imaging studiesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPhysicsen_US
dc.subject.hlbsecondlevelNuclear Engineering and Radiological Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, U.S.A.en_US
dc.identifier.pmid8472029en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30889/1/0000558.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0969-8043(93)90130-3en_US
dc.identifier.sourceApplied Radiation and Isotopesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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