A Joint Prediction of the Folding Types of 1490 Human Proteins from their Genetic Codons
dc.contributor.author | Chou, James Jeiwen | en_US |
dc.contributor.author | Zhang, Chun-Ting | en_US |
dc.date.accessioned | 2006-04-10T15:50:18Z | |
dc.date.available | 2006-04-10T15:50:18Z | |
dc.date.issued | 1993-03-21 | en_US |
dc.identifier.citation | Chou, James Jeiwen, Zhang, Chun-Ting (1993/03/21)."A Joint Prediction of the Folding Types of 1490 Human Proteins from their Genetic Codons." Journal of Theoretical Biology 161(2): 251-262. <http://hdl.handle.net/2027.42/30902> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WMD-45P67FF-5F/2/0448b5e67472c18d35c9d0436bbea30d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30902 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8331952&dopt=citation | en_US |
dc.description.abstract | The codon usages for 1490 human proteins have been published by Wada et al. (1990). Based on these data, the frequencies of occurrence of 20 amino acids for each of the 1490 proteins have been calculated according to the genetic codes. Proteins are generally classified into five folding types, i.e. the [alpha], [beta], [alpha] + [beta], [alpha]/[beta] and [zeta] (irregular) types. The folding type of a protein is correlated to its amino acid composition. By means of three methods established by different investigators, the folding type for each of the 1490 human proteins has been predicted. It has been demonstrated that the accuracy of prediction for the 1490 human proteins is at least 80% by examining the predicted results of some structurally known proteins with these methods. There are only six proteins for which there is uncertainty about their folding types as completely inconsistent results were obtained when predicted with the three different methods. For the remaining 1484 human proteins the numbers of [alpha], [beta], [alpha] + [beta], [alpha]/[beta], and [zeta] folding type proteins were found to be 128, 235, 169, 933 and 19, respectively, suggesting that the [alpha]/[beta] type proteins would predominate in this set of human proteins. The occurrence frequencies of bases in the first, second and third codon position for each folding type of protein have been calculated. It is shown that the folding type of a protein is strongly dependent on the ratio of frequency of base G in the first codon position with that in the second codon position. The biological implication of the results has been discussed. | en_US |
dc.format.extent | 343244 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | A Joint Prediction of the Folding Types of 1490 Human Proteins from their Genetic Codons | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Physics, University of Michigan, Ann Arbor, MI 48109, U.S.A | en_US |
dc.contributor.affiliationother | Department of Physics, Tianjin University, Tianjin 300072, China | en_US |
dc.identifier.pmid | 8331952 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30902/1/0000571.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1006/jtbi.1993.1053 | en_US |
dc.identifier.source | Journal of Theoretical Biology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.