The effects of transforming growth factor alpha and somatostatin on regenerating hepatocytes in the rat
dc.contributor.author | Hashimoto, Masaji | en_US |
dc.contributor.author | Kothary, Piyush C. | en_US |
dc.contributor.author | Raper, Steven E. | en_US |
dc.date.accessioned | 2006-04-10T15:50:32Z | |
dc.date.available | 2006-04-10T15:50:32Z | |
dc.date.issued | 1993-03-05 | en_US |
dc.identifier.citation | Hashimoto, Masaji, Kothary, Piyush C., Raper, Steven E. (1993/03/05)."The effects of transforming growth factor alpha and somatostatin on regenerating hepatocytes in the rat." Regulatory Peptides 44(1): 49-59. <http://hdl.handle.net/2027.42/30907> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0S-47GH7R7-37/2/6d2f124631e0cdafc51691c9abf08d8f | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30907 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8097889&dopt=citation | en_US |
dc.description.abstract | Transforming growth factor alpha (TGF[alpha]) stimulates DNA synthesis in adult rat hepatocytes, and plays a physiological role after partial hepatectomy by an autocrine mechanism. Somatostatin (SS-14) is a potent inhibitor of gastrointestinal function and inhibits proliferation in various cell types. We examined the proliferative effect of TGF[alpha] and the inhibitory effect of SS-14 on hepatocytes isolated at various times after partial hepatectomy. To study the mechanism of SS-14 further, we treated rats with the long acting SS-14 analog, octreotide, before or after 70% hepatectomy to determine whether or not a differential effect could be seen. We confirmed the proliferative effects of TGF[alpha], and the inhibitory action of SS-14 in the early phase of liver regeneration in vitro. Regenerating hepatocytes isolated from hepatectomized livers respond to TGF[alpha] only at early time points (2 h) but do not respond to SS-14. In addition, the long acting SS-14 analog, octreotide, inhibited hepatic regeneration only when administered prior to hepatectomy. We conclude that exogenous peptide stimulation is effective only in the early phase of the hepatic proliferative response. After the initial changes brought about by hepatectomy, subsequent steps of the regenerative process appear refractory to external stimuli. | en_US |
dc.format.extent | 802911 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The effects of transforming growth factor alpha and somatostatin on regenerating hepatocytes in the rat | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.identifier.pmid | 8097889 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30907/1/0000576.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0167-0115(93)90129-V | en_US |
dc.identifier.source | Regulatory Peptides | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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