Chromosomal aberrations in mouse lymphocytes exposed in vivo and in vitro to aliphatic epoxides
dc.contributor.author | Das, L. | en_US |
dc.contributor.author | Das, Salil K. | en_US |
dc.contributor.author | Chu, Ernest H. Y. | en_US |
dc.contributor.author | Sinsheimer, Joseph E. | en_US |
dc.date.accessioned | 2006-04-10T15:50:45Z | |
dc.date.available | 2006-04-10T15:50:45Z | |
dc.date.issued | 1993-03 | en_US |
dc.identifier.citation | Das, L., Das, S. K., Chu, E. H. Y., Sinsheimer, J. E. (1993/03)."Chromosomal aberrations in mouse lymphocytes exposed in vivo and in vitro to aliphatic epoxides." Mutation Research/Genetic Toxicology 299(1): 19-24. <http://hdl.handle.net/2027.42/30912> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B73FB-474WXNM-1C/2/6274c619e825054adddc3272e200e216 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30912 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7679188&dopt=citation | en_US |
dc.description.abstract | Mouse lymphocytes in vivo or in vitro were exposed for 24 h to 4 aliphatic epoxides, glycidyl 1-naphthyl ether, glycidyl 4-nitrophenyl ether, 1-naphthylpropylene oxide and trichloropropylene oxide (TCPO), and tested for the induction of chromosomal aberrations (CA). These epoxides were among the most genotoxic aliphatic epoxides in our previous studies. With the exception of TCPO, the test epoxides caused significant increases in CA in vivo compared to a negative control. There were concentration related increases in CA for all 4 epoxides in vitro and TCPO produced the greatest cellular toxicity and genotoxic effects towards cultured lymphocytes. The difference in the order of genotoxicity for the two test systems can be explained on the basis of a much shorter half-life for TCPO than for the other epoxides. | en_US |
dc.format.extent | 403478 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Chromosomal aberrations in mouse lymphocytes exposed in vivo and in vitro to aliphatic epoxides | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 7679188 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30912/1/0000581.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-1218(93)90114-S | en_US |
dc.identifier.source | Mutation Research/Genetic Toxicology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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