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Retroviruses: delivery vehicle to the liver
dc.contributor.authorGrossman, Mariannen_US
dc.contributor.authorWilson, James M.en_US
dc.date.accessioned2006-04-10T15:53:53Z
dc.date.available2006-04-10T15:53:53Z
dc.date.issued1993-02en_US
dc.identifier.citationGrossman, Mariann, Wilson, James M. (1993/02)."Retroviruses: delivery vehicle to the liver." Current Opinion in Genetics &amp; Development 3(1): 110-114. <http://hdl.handle.net/2027.42/30982>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6VS0-4GT1M5R-N/2/f4cbe1f61faf54ac11acb9ef34506987en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30982
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8453268&dopt=citationen_US
dc.description.abstractLiver-directed gene therapy holds great promise for the treatment of inherited metabolic disease. Two strategies have emerged. Ex vivo gene therapy involves the transplantation of autologous hepatocytes transduced with recombinant retroviruses while in culture. The feasibility of this approach has been demonstrated in several animal models, and a human trial has been initiated. An alternative strategy uses recombinant viruses to deliver the transgene directly to hepatocytes in vivo.en_US
dc.format.extent577603 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleRetroviruses: delivery vehicle to the liveren_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arbor, Michigan, USAen_US
dc.identifier.pmid8453268en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30982/1/0000657.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/S0959-437X(05)80350-8en_US
dc.identifier.sourceCurrent Opinion in Genetics &amp; Developmenten_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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