Region specific expression of furin mRNA in the rat brain
dc.contributor.author | Day, Robert | en_US |
dc.contributor.author | Schafer, Martin K.-H. | en_US |
dc.contributor.author | Cullinan, William E. | en_US |
dc.contributor.author | Watson, Stanley J. | en_US |
dc.contributor.author | Chretien, Michel | en_US |
dc.contributor.author | Seidah, Nabil G. | en_US |
dc.date.accessioned | 2006-04-10T15:55:04Z | |
dc.date.available | 2006-04-10T15:55:04Z | |
dc.date.issued | 1993-01-04 | en_US |
dc.identifier.citation | Day, Robert, Schafer, Martin K. -H., Cullinan, William E., Watson, Stanley J., Chretien, Michel, Seidah, Nabil G. (1993/01/04)."Region specific expression of furin mRNA in the rat brain." Neuroscience Letters 149(1): 27-30. <http://hdl.handle.net/2027.42/31008> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0G-485TTNY-353/2/ea8e3c5907b1d7e4558e364edbd360f4 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31008 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8469374&dopt=citation | en_US |
dc.description.abstract | The distribution of furin mRNA was examined in the rat central nervous system. Northern blot analysis reveals the presence of a 4.4 kb band in all brain tissues examined. In situ hybridization analysis of frozen rat brain sections using a radioactively labeled antisense cRNA probe to rat furin demonstrated moderate to low levels of expression in both neuronal and non-neuronal tissue in all areas examined. Interestingly, higher levels of furin were expressed in selective regions which include the ventricles (the choroid plexus and ependymal cells), the islands of Calleja, the hippocampus and the pineal gland. The ubiquitous localization of furin in the brain is consistent with its postulated role as a vital convertase important in the processing of proporteins negotiating the constitutive pathway of secretion. However, the higher expression of furin mRNA in distinct brain areas suggests a more active role in the processing of proproteins synthesized in these tissues. | en_US |
dc.format.extent | 380943 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Region specific expression of furin mRNA in the rat brain | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | J.A. DeSève Laboratorie of Biochemical, Clinical Research Institute of Montreal, Montreal, Que., Canada | en_US |
dc.contributor.affiliationother | Anatomisches Institut, Johannes Gutenberg-Universitat, Mainz, FRG | en_US |
dc.contributor.affiliationother | J.A. DeSève Laboratorie of Molecular Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Que., Canada | en_US |
dc.contributor.affiliationother | J.A. DeSève Laboratorie of Biochemical, Clinical Research Institute of Montreal, Montreal, Que., Canada | en_US |
dc.identifier.pmid | 8469374 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31008/1/0000683.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0304-3940(93)90339-M | en_US |
dc.identifier.source | Neuroscience Letters | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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