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Autoradiographic study of the effects of pulsed electromagnetic fields on bone and cartilage growth in juvenile rats

dc.contributor.authorWilmot, Janice J.en_US
dc.contributor.authorChiego, Jr, D. J.en_US
dc.contributor.authorCarlson, David S.en_US
dc.contributor.authorHanks, Carl T.en_US
dc.contributor.authorMoskwa, James J.en_US
dc.date.accessioned2006-04-10T15:56:26Z
dc.date.available2006-04-10T15:56:26Z
dc.date.issued1993-01en_US
dc.identifier.citationWilmot, Janice J., Chiego, Jr, D. J., Carlson, D. S., Hanks, C. T., Moskwa, J. J. (1993/01)."Autoradiographic study of the effects of pulsed electromagnetic fields on bone and cartilage growth in juvenile rats." Archives of Oral Biology 38(1): 67-74. <http://hdl.handle.net/2027.42/31040>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T4J-4BWHKD8-186/2/b808c192d1f3d62f12d6ec090e8bc778en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/31040
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8442723&dopt=citationen_US
dc.description.abstractApplication of pulsed electromagnetic fields (PEMF) has been used in growth and repair of non-union bone fractures. The similarities between the fibrocartilage callus in non-union bone fractures and the secondary cartilage in the mandibular condyle, both histologically and functionally, lead naturally to study the effects of PEMFs on growth in the condyle. The purposes of this study were: (1) to describe the effects of PEMFs on the growth of the condyle using autoradiography, [3H]-proline and [3H]-thymidine, and (2) to differentiate between the effects of the magnetic and electrical components of the field. Male pre-adolescent Sprague-Dawley rats (28 days old) were divided into three experimental groups of five animals each: (1) PEMF-magnetic (M), (2) PEMF-electrical (E) and (3) control, and were examined at three different times--3, 7 and 14 days of exposure. Each animal was exposed to the field for 8 h per day. Histological coronal sections were processed for quantitative autoradiography to determine the mitotic activity of the condylar cartilage and the amount of bone deposition. The PEMF (magnetic or electrical) had statistically significant effects only on the thickness of the articular zone, with the thickness in the PEMF-M group being the most reduced. Length of treatment was associated with predictable significant changes in the thickness of the condylar cartilage zones and the amount of bone deposition. As the animals aged, less condylar growth was observed and generally the highest mean thicknesses were found in the 3- and 7-day groups; likewise as more bone was deposited, the 7-day measurements of proline-band thickness were significantly greater than the 3-day measurements. Thus, the PEMF-M had a negative effect on the chondrogenic layer of the articular zone, but no other chondrogenic or osteogenic effects were noted.en_US
dc.format.extent999130 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleAutoradiographic study of the effects of pulsed electromagnetic fields on bone and cartilage growth in juvenile ratsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelDentistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Orthodontics and Pediatrie Dentistry, Schools of Dentistry and Medicine, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Cariology and General Dentistry and Biological and Materials Sciences, Schools of Dentistry and Medicine, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Orthodontics and Pediatrie Dentistry, Schools of Dentistry and Medicine, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Oral Medicine, Pathology and Surgery, Schools of Dentistry and Medicine, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Internal Medicine-Nuclear Medicine, Schools of Dentistry and Medicine, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.identifier.pmid8442723en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/31040/1/0000717.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0003-9969(93)90157-Hen_US
dc.identifier.sourceArchives of Oral Biologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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