Autoradiographic study of the effects of pulsed electromagnetic fields on bone and cartilage growth in juvenile rats

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dc.contributor.author Wilmot, Janice J. en_US
dc.contributor.author Chiego, Jr, D. J. en_US
dc.contributor.author Carlson, David S. en_US
dc.contributor.author Hanks, C. T. en_US
dc.contributor.author Moskwa, James J. en_US
dc.date.accessioned 2006-04-10T15:56:26Z
dc.date.available 2006-04-10T15:56:26Z
dc.date.issued 1993-01 en_US
dc.identifier.citation Wilmot, Janice J., Chiego, Jr, D. J., Carlson, D. S., Hanks, C. T., Moskwa, J. J. (1993/01)."Autoradiographic study of the effects of pulsed electromagnetic fields on bone and cartilage growth in juvenile rats." Archives of Oral Biology 38(1): 67-74. <http://hdl.handle.net/2027.42/31040> en_US
dc.identifier.uri http://www.sciencedirect.com/science/article/B6T4J-4BWHKD8-186/2/b808c192d1f3d62f12d6ec090e8bc778 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/31040
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8442723&dopt=citation en_US
dc.description.abstract Application of pulsed electromagnetic fields (PEMF) has been used in growth and repair of non-union bone fractures. The similarities between the fibrocartilage callus in non-union bone fractures and the secondary cartilage in the mandibular condyle, both histologically and functionally, lead naturally to study the effects of PEMFs on growth in the condyle. The purposes of this study were: (1) to describe the effects of PEMFs on the growth of the condyle using autoradiography, [3H]-proline and [3H]-thymidine, and (2) to differentiate between the effects of the magnetic and electrical components of the field. Male pre-adolescent Sprague-Dawley rats (28 days old) were divided into three experimental groups of five animals each: (1) PEMF-magnetic (M), (2) PEMF-electrical (E) and (3) control, and were examined at three different times--3, 7 and 14 days of exposure. Each animal was exposed to the field for 8 h per day. Histological coronal sections were processed for quantitative autoradiography to determine the mitotic activity of the condylar cartilage and the amount of bone deposition. The PEMF (magnetic or electrical) had statistically significant effects only on the thickness of the articular zone, with the thickness in the PEMF-M group being the most reduced. Length of treatment was associated with predictable significant changes in the thickness of the condylar cartilage zones and the amount of bone deposition. As the animals aged, less condylar growth was observed and generally the highest mean thicknesses were found in the 3- and 7-day groups; likewise as more bone was deposited, the 7-day measurements of proline-band thickness were significantly greater than the 3-day measurements. Thus, the PEMF-M had a negative effect on the chondrogenic layer of the articular zone, but no other chondrogenic or osteogenic effects were noted. en_US
dc.format.extent 999130 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Elsevier en_US
dc.title Autoradiographic study of the effects of pulsed electromagnetic fields on bone and cartilage growth in juvenile rats en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Dentistry en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Orthodontics and Pediatrie Dentistry, Schools of Dentistry and Medicine, University of Michigan, Ann Arbor, MI 48109, U.S.A. en_US
dc.contributor.affiliationum Department of Cariology and General Dentistry and Biological and Materials Sciences, Schools of Dentistry and Medicine, University of Michigan, Ann Arbor, MI 48109, U.S.A. en_US
dc.contributor.affiliationum Department of Orthodontics and Pediatrie Dentistry, Schools of Dentistry and Medicine, University of Michigan, Ann Arbor, MI 48109, U.S.A. en_US
dc.contributor.affiliationum Department of Oral Medicine, Pathology and Surgery, Schools of Dentistry and Medicine, University of Michigan, Ann Arbor, MI 48109, U.S.A. en_US
dc.contributor.affiliationum Department of Internal Medicine-Nuclear Medicine, Schools of Dentistry and Medicine, University of Michigan, Ann Arbor, MI 48109, U.S.A. en_US
dc.identifier.pmid 8442723 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/31040/1/0000717.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1016/0003-9969(93)90157-H en_US
dc.identifier.source Archives of Oral Biology en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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