Atrioventricular conduction in children of women with systemic lupus erythematosus
dc.contributor.author | Goble, Monica Martin | en_US |
dc.contributor.author | Dick, Macdonald II | en_US |
dc.contributor.author | McCune, William Joseph | en_US |
dc.contributor.author | Ellsworth, Janet | en_US |
dc.contributor.author | Sullivan, Donita B. | en_US |
dc.contributor.author | Stern, Aaron M. | en_US |
dc.date.accessioned | 2006-04-10T15:56:43Z | |
dc.date.available | 2006-04-10T15:56:43Z | |
dc.date.issued | 1993-01-01 | en_US |
dc.identifier.citation | Goble, Monica Martin, Dick, II, Macdonald, McCune, W. Joseph, Ellsworth, Janet, Sullivan, Donita B., Stern, Aaron M. (1993/01/01)."Atrioventricular conduction in children of women with systemic lupus erythematosus." The American Journal of Cardiology 71(1): 94-98. <http://hdl.handle.net/2027.42/31047> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T10-4C76BDW-29/2/e23b67f11cfb1bb988764cb5706d8000 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31047 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8420243&dopt=citation | en_US |
dc.description.abstract | The neonatal lupus syndrome consists of transient cutaneous lupus lesions or permanent congenital complete heart block (or hepatic fibrosis), or both, in infants born to mothers with systemic lupus erythematosus (SLE). The frequency of conduction abnormalities was examined in 86 offspring of 53 women affected by SLE. Electrocardiograms from the offspring demonstrated normal sinus rhythm in 84 of 86 offspring. The PR interval was normal for age (95th percentile (i.e., first-degree heart block) for both age and heart rate. The PR interval of the other 6 subjects with first-degree heart block for age or heart rate (>=95th percentile) was <=0.18 second. In contrast, using a rank assignment of PR intervals in relation to heart rate and age derived from published standards, grouped data indicated that heart rate adjusted for age was greater and PR interval adjusted for heart rate longer in offspring of mothers who had the onset of SLE before or during pregnancy than in the normal population; this observation did not hold for offspring whose mothers developed SLE after the pregnancy. These findings indicate that offspring of mothers with SLE, even in the absence of an abnormal electrocardiogram, may have experienced a maternal internal environment that produces subclinical changes in atrioventricular conduction. However, newborns with a normal pulse rate are unlikely to have significant abnormalities in atrioventricular conduction and do not need screening electrocardiograms at birth. | en_US |
dc.format.extent | 526939 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Atrioventricular conduction in children of women with systemic lupus erythematosus | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Divisions of Pediatric Cardiology and Pediatric Rheumatology, Department of Pediatrics, and the Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Divisions of Pediatric Cardiology and Pediatric Rheumatology, Department of Pediatrics, and the Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Divisions of Pediatric Cardiology and Pediatric Rheumatology, Department of Pediatrics, and the Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Divisions of Pediatric Cardiology and Pediatric Rheumatology, Department of Pediatrics, and the Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Divisions of Pediatric Cardiology and Pediatric Rheumatology, Department of Pediatrics, and the Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Divisions of Pediatric Cardiology and Pediatric Rheumatology, Department of Pediatrics, and the Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.identifier.pmid | 8420243 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31047/1/0000724.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-9149(93)90717-Q | en_US |
dc.identifier.source | The American Journal of Cardiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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