Immunization of institutionalized asthmatic children and patients with psychomotor retardation using live attenuated cold-adapted reassortment influenza A H1N1, H3N2 and B vaccines
dc.contributor.author | Miyazaki, Chiaki | en_US |
dc.contributor.author | Nakayama, Minako | en_US |
dc.contributor.author | Tanaka, Yoshifumi | en_US |
dc.contributor.author | Kusuhara, Koichi | en_US |
dc.contributor.author | Okada, Kenji | en_US |
dc.contributor.author | Tokugawa, Ken | en_US |
dc.contributor.author | Ueda, Kohji | en_US |
dc.contributor.author | Shibata, Rumiko | en_US |
dc.contributor.author | Nishima, Sankei | en_US |
dc.contributor.author | Yamane, Nobuhisa | en_US |
dc.contributor.author | Maassab, Hunein F. | en_US |
dc.date.accessioned | 2006-04-10T15:58:52Z | |
dc.date.available | 2006-04-10T15:58:52Z | |
dc.date.issued | 1993 | en_US |
dc.identifier.citation | Miyazaki, Chiaki, Nakayama, Minako, Tanaka, Yoshifumi, Kusuhara, Koichi, Okada, Kenji, Tokugawa, Ken, Ueda, Kohji, Shibata, Rumiko, Nishima, Sankei, Yamane, Nobuhisa, Maassab, H. F. (1993)."Immunization of institutionalized asthmatic children and patients with psychomotor retardation using live attenuated cold-adapted reassortment influenza A H1N1, H3N2 and B vaccines." Vaccine 11(8): 853-858. <http://hdl.handle.net/2027.42/31097> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TD4-476W55C-FD/2/eac6e988f0cb68ce4b41c8b847a7bc37 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31097 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8356846&dopt=citation | en_US |
dc.description.abstract | Live attenuated cold-adapted reassortant (CR) influenza virus vaccines were evaluated in institutionalized asthmatic children and severe psychomotor-retarded (SPR) patients. Almost all the vaccines were seropositive to the vaccine strains before immunization. Trivalent CR vaccine (containing A H1N1 (CR-125), A H3N2 (CR-149) and B (CRB-117)), bivalent CR vaccine (CR-125 and CR-149) and monovalent CRB-117 were inoculated to 19 asthmatic children and 36 and 16 SPR patients, respectively. Overall 49, 22, 11% of vaccinees were infected by A H1N1, A H3N2 or B vaccine viruses, respectively, as indicated by significant haemagglutination-inhibition (HI) antibody titre rises 4 weeks after inoculation. No severe adverse reactions associated with CR vaccination were observed in the handicapped patients. A nosocomial outbreak of influenza A H1N1 occurred in the ward with asthmatic children, but none of the 19 CR-trivalent vaccinees became infected. However, five of 20 non-vaccinees in the same ward, and ten of 30 vaccinees in another ward that received inactivated split vaccine became infected. The CR vaccines demonstrated significant protective effects against natural exposure to the A H1N1 virus, and were well tolerated and safe when given to patients with bronchial asthma and severe psychomotor retardation. | en_US |
dc.format.extent | 614134 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Immunization of institutionalized asthmatic children and patients with psychomotor retardation using live attenuated cold-adapted reassortment influenza A H1N1, H3N2 and B vaccines | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Faculty of Medicine, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812, Japan | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Faculty of Medicine, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812, Japan | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Faculty of Medicine, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812, Japan | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Faculty of Medicine, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812, Japan | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Faculty of Medicine, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812, Japan | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Faculty of Medicine, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812, Japan | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Faculty of Medicine, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812, Japan | en_US |
dc.contributor.affiliationother | The National Minami Fukuoka Chest Hospital, 4-39-1, Yakatabaru, Minami-ku, Fukuoka 815, Japan | en_US |
dc.contributor.affiliationother | The National Minami Fukuoka Chest Hospital, 4-39-1, Yakatabaru, Minami-ku, Fukuoka 815, Japan | en_US |
dc.contributor.affiliationother | Department of Laboratory Medicine, Kumamoto University Medical School, 1-1-1, Honjo, Kumamoto 860, Japan | en_US |
dc.identifier.pmid | 8356846 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31097/1/0000775.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0264-410X(93)90361-Z | en_US |
dc.identifier.source | Vaccine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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