The effects of methamphetamine and cocaine on motor behavior and extracellular dopamine in the ventral striatum of Lewis versus Fischer 344 rats
dc.contributor.author | Camp, Dianne M. | en_US |
dc.contributor.author | Browman, Kaitlin E. | en_US |
dc.contributor.author | Robinson, Terry E. | en_US |
dc.date.accessioned | 2006-04-10T17:41:07Z | |
dc.date.available | 2006-04-10T17:41:07Z | |
dc.date.issued | 1994-12-30 | en_US |
dc.identifier.citation | Camp, Dianne M., Browman, Kaitlin E., Robinson, Terry E. (1994/12/30)."The effects of methamphetamine and cocaine on motor behavior and extracellular dopamine in the ventral striatum of Lewis versus Fischer 344 rats." Brain Research 668(1-2): 180-193. <http://hdl.handle.net/2027.42/31110> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-47XN88X-S/2/3b8af0e2ab7d7df042e94b5462b13c7b | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31110 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7704604&dopt=citation | en_US |
dc.description.abstract | The effects of an acute systemic injection of methamphetamine (mAMP) or cocaine (COC) on motor behavior (stereotypy, locomotor activity, and rearing) and extracellular dopamine (DA) in the ventral striatum were compared in Lewis (LEW) versus Fischer 344 (F344) rats, using in vivo microdialysis in awake freely moving animals. In addition, the behavioral response to repeated mAMP injections (i.e. sensitization) was characterized in LEW and F344 rats, as was the possibility of strain differences in drug pharmacokinetics. The major findings were: (i) LEW rats showed greater behavioral activation to an acute injection of both mAMP and COC, as indicated by a shift to the left in the dose-effect curves relative to F344 rats. (ii) LEW rats were more susceptible to mAMP sensitization. (iii) An acute injection of mAMP or COC enhanced the extracellular concentration of DA to a greater extent in LEW rats, as indicated by a significant shift to the left in the dose-effect curve relative to F344 rats. (iv) Strain differences in the behavioral and neurochemical effects of these drugs were characterized largely by differences in the duration of the drug response. (v) LEW rats had higher plasma and brain levels of mAMP and COC than F344 rats, suggesting that strain differences in pharmacokinetics may contribute to strain differences in the behavioral and neurochemical effects of these drugs. | en_US |
dc.format.extent | 1497329 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The effects of methamphetamine and cocaine on motor behavior and extracellular dopamine in the ventral striatum of Lewis versus Fischer 344 rats | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychology and Neuroscience Program, University of Michigan, Neuroscience Laboratory Building, 1103 East Huron Street, Ann Arbor, MI 48104-1687, USA | en_US |
dc.contributor.affiliationum | Department of Psychology and Neuroscience Program, University of Michigan, Neuroscience Laboratory Building, 1103 East Huron Street, Ann Arbor, MI 48104-1687, USA | en_US |
dc.contributor.affiliationum | Department of Psychology and Neuroscience Program, University of Michigan, Neuroscience Laboratory Building, 1103 East Huron Street, Ann Arbor, MI 48104-1687, USA | en_US |
dc.identifier.pmid | 7704604 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31110/1/0000006.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(94)90523-1 | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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