Evaluation of the abuse liability of aminorex
dc.contributor.author | Woolverton, William L. | en_US |
dc.contributor.author | Massey, B. W. | en_US |
dc.contributor.author | Winger, Gail D. | en_US |
dc.contributor.author | Patrick, G. A. | en_US |
dc.contributor.author | Harris, L. S. | en_US |
dc.date.accessioned | 2006-04-10T17:42:51Z | |
dc.date.available | 2006-04-10T17:42:51Z | |
dc.date.issued | 1994-12 | en_US |
dc.identifier.citation | Woolverton, W. L., Massey, B. W., Winger, G., Patrick, G. A., Harris, L. S. (1994/12)."Evaluation of the abuse liability of aminorex." Drug and Alcohol Dependence 36(3): 187-192. <http://hdl.handle.net/2027.42/31143> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T63-4BPB0BR-4/2/dfe6aaeb938221f16c53d9e4e1238e50 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31143 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7889809&dopt=citation | en_US |
dc.description.abstract | Aminorex is a cyclic phenylisopropylamine that has been marketed as an anorectic. Despite obvious pharmacological similarities to the amphetamines, little is known about its liability for abuse. In the present study, one group of rhesus monkeys (n = 3) was prepared with intravenous catheters and allowed to self-administer either methohexital or saline in daily experimental sessions. When methohexital and saline self-administration were stable and clearly different, various doses of aminorex (0.001-0.1 mg/kg/injection) were made available for self-administration. Aminorex maintained self-administration above that maintained by saline and slightly lower than that maintained by methohexital in all monkeys. The discriminative stimulus effects of aminorex were evaluated in rhesus monkeys trained to discriminate d-amphetamine (n = 3) or pentobarbital (n = 4) from saline. Aminorex substituted completely for d-amphetamine as a discriminative stimulus but engendered little or no pentobarbital-appropriate responding. Aminorex stimulated locomotor activity in mice and exacerbated the withdrawal syndrome in rats that were dependent upon pentobarbital. These findings indicate that aminorex is a psychomotor stimulant that would be predicted to have significant d-amphetamine-like abuse liability in humans. | en_US |
dc.format.extent | 710761 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Evaluation of the abuse liability of aminorex | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Social Work | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry, University of Chicago, Chicago, IL, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry, University of Chicago, Chicago, IL, USA | en_US |
dc.contributor.affiliationother | Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia, Richmond, VA, USA | en_US |
dc.contributor.affiliationother | Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia, Richmond, VA, USA | en_US |
dc.identifier.pmid | 7889809 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31143/1/0000040.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0376-8716(94)90144-9 | en_US |
dc.identifier.source | Drug and Alcohol Dependence | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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