CFTR Does Not Alter Acidification of L Cell Endosomes
dc.contributor.author | Root, Karen V. | en_US |
dc.contributor.author | Engelhardt, John F. | en_US |
dc.contributor.author | Post, Marc A. | en_US |
dc.contributor.author | Wilson, James W. | en_US |
dc.contributor.author | Vandyke, R. W. | en_US |
dc.date.accessioned | 2006-04-10T17:45:05Z | |
dc.date.available | 2006-04-10T17:45:05Z | |
dc.date.issued | 1994-11-30 | en_US |
dc.identifier.citation | Root K. V., , Engelhardt J. F., , Post M., , Wilson J. W., , Vandyke R. W., (1994/11/30)."CFTR Does Not Alter Acidification of L Cell Endosomes." Biochemical and Biophysical Research Communications 205(1): 396-401. <http://hdl.handle.net/2027.42/31184> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WBK-45PMJV4-23/2/324d7a16b561e35dd41c5db1f8583c3d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31184 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7528013&dopt=citation | en_US |
dc.description.abstract | Endosomes from L cells, transduced with the CFTR gene, and the parental line, which does not express detectable levels of CFTR, were loaded with FITC-dextran, isolated and the initial rates of acidification, steady-state pHi, and proton leak rates were compared over a range of chloride concentrations (0-140 mM). Values for these parameters were similar for endosomes from both cell lines in the presence and absence of cAMP and PKA. These results indicate that CFTR does not alter L cell endosome acidification, possibly due to an adequate intrinsic CI- conductance or to a failure to incorporate sufficient functional CFTR or a necessary co-factor in endocytic membranes. | en_US |
dc.format.extent | 380131 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | CFTR Does Not Alter Acidification of L Cell Endosomes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | 6520 MSRB-I, Department of Internal Medicine and Cystic Fibrosis Center, University of Michigan, Ann Arbor, MI, USA. | en_US |
dc.contributor.affiliationum | 6520 MSRB-I, Department of Internal Medicine and Cystic Fibrosis Center, University of Michigan, Ann Arbor, MI, USA; Institute for Gene Therapy, University of Pennsylvania, The Wistar Institute, Philadelphia, PA, USA. | en_US |
dc.contributor.affiliationum | Department of Physiology, University of Michigan, Ann Arbor, MI, USA. | en_US |
dc.contributor.affiliationum | 6520 MSRB-I, Department of Internal Medicine and Cystic Fibrosis Center, University of Michigan, Ann Arbor, MI, USA; Institute for Gene Therapy, University of Pennsylvania, The Wistar Institute, Philadelphia, PA, USA. | en_US |
dc.contributor.affiliationum | 6520 MSRB-I, Department of Internal Medicine and Cystic Fibrosis Center, University of Michigan, Ann Arbor, MI, USA. | en_US |
dc.identifier.pmid | 7528013 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31184/1/0000085.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1006/bbrc.1994.2678 | en_US |
dc.identifier.source | Biochemical and Biophysical Research Communications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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