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Spontaneous Calcium Oscillations in Clonal Endocrine Pancreatic Glucagon-Secreting Cells
dc.contributor.authorBode, H. P.en_US
dc.contributor.authorYule, David I.en_US
dc.contributor.authorFehmann, Hans-Christophen_US
dc.contributor.authorGoke, B.en_US
dc.contributor.authorWilliams, John A.en_US
dc.date.accessioned2006-04-10T17:45:08Z
dc.date.available2006-04-10T17:45:08Z
dc.date.issued1994-11-30en_US
dc.identifier.citationBode H. P., , Yule D. I., , Fehmann H. C., , Goke B., , Williams J. A., (1994/11/30)."Spontaneous Calcium Oscillations in Clonal Endocrine Pancreatic Glucagon-Secreting Cells." Biochemical and Biophysical Research Communications 205(1): 435-440. <http://hdl.handle.net/2027.42/31185>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-45PMJV4-29/2/3391c2a16ad090e306bf13444cd19f72en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/31185
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7999060&dopt=citationen_US
dc.description.abstractMeasurements of the cytosolic calcium concentration in single cells of the clonal endocrine pancreatic glucagon-secreting cell line INR1 G9 revealed the existence of spontaneous calcium oscillations in 20 - 70 % of these cells. Inhibition of these spontaneous oscillations by thapsigargin as well as the phospholipase C inhibitor U 73122 demonstrated involvement of calcium release from intracellular stores, probably mediated by a high basal activity of phospholipase C. Removal of extracellular calcium but not the L-type calcium channel antagonists verapamil or nifedipine terminated the spontaneous oscillations, suggesting that calcium influx by a pathway distinct from L-type channels contributed to the oscillations. Similar spontaneous calcium oscillations could be the pacemaker of pulsatile glucagon release in endocrine pancreatic A-cells.en_US
dc.format.extent306722 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleSpontaneous Calcium Oscillations in Clonal Endocrine Pancreatic Glucagon-Secreting Cellsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, Philips University of Marburg, Marburg, Germany; Department of Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationumDepartment of Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationumDepartment of Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationotherClinical Research Unit for Gastrointestinal Endocrinology, Philips University of Marburg, Marburg, Germany.en_US
dc.contributor.affiliationotherClinical Research Unit for Gastrointestinal Endocrinology, Philips University of Marburg, Marburg, Germany.en_US
dc.identifier.pmid7999060en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/31185/1/0000086.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1006/bbrc.1994.2684en_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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