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Prodynorphin-derived peptide expression in primate cortex and striatum

dc.contributor.authorHealy, Daniel J.en_US
dc.contributor.authorMeador-Woodruff, James H.en_US
dc.date.accessioned2006-04-10T17:46:47Z
dc.date.available2006-04-10T17:46:47Z
dc.date.issued1994-11en_US
dc.identifier.citationHealy, D. J., Meador-Woodruff, J. H. (1994/11)."Prodynorphin-derived peptide expression in primate cortex and striatum." Neuropeptides 27(5): 277-284. <http://hdl.handle.net/2027.42/31211>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WNR-4C837MJ-MB/2/d5c77356357b2626d94c07b59843d25fen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/31211
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7862260&dopt=citationen_US
dc.description.abstractThe distributions of four prodynorphin-derived peptides, dynorphin A (1-17), dynorphin A (1-8), dynorphin B, and [alpha]-neo-endorphin were determined in 10 cortical regions and the striatum of the old world monkey (Macaca nemestrina). [alpha]-neo-endorphin was the most abundant peptide in both cortex and striatum. The concentrations of all four peptides were significantly greater in the striatum compared to the cortex. In general, concentrations of each peptide tended to be higher in allocortex than in neocortex. Possible inter- and intradomain processing differences, as estimated by ratios of these peptides, did not vary within cortex, but the intradomain peptide ratio, dyn A (1-17)/dyn A (1-8), was significantly greater in cortex than in striatum. These results indicate that prodynorphin is, in some ways, uniquely processed in the primate. Particularly unusual is the relatively low abundance of prodynorphin-derived products in the cortex, in the face of moderately high levels of kappa opiate receptor expression.en_US
dc.format.extent759088 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleProdynorphin-derived peptide expression in primate cortex and striatumen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of of Psychiatry, Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109-0720, USAen_US
dc.contributor.affiliationumDepartment of of Psychiatry, Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109-0720, USAen_US
dc.identifier.pmid7862260en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/31211/1/0000113.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0143-4179(94)90108-2en_US
dc.identifier.sourceNeuropeptidesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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