Prodynorphin-derived peptide expression in primate cortex and striatum
dc.contributor.author | Healy, Daniel J. | en_US |
dc.contributor.author | Meador-Woodruff, James H. | en_US |
dc.date.accessioned | 2006-04-10T17:46:47Z | |
dc.date.available | 2006-04-10T17:46:47Z | |
dc.date.issued | 1994-11 | en_US |
dc.identifier.citation | Healy, D. J., Meador-Woodruff, J. H. (1994/11)."Prodynorphin-derived peptide expression in primate cortex and striatum." Neuropeptides 27(5): 277-284. <http://hdl.handle.net/2027.42/31211> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WNR-4C837MJ-MB/2/d5c77356357b2626d94c07b59843d25f | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31211 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7862260&dopt=citation | en_US |
dc.description.abstract | The distributions of four prodynorphin-derived peptides, dynorphin A (1-17), dynorphin A (1-8), dynorphin B, and [alpha]-neo-endorphin were determined in 10 cortical regions and the striatum of the old world monkey (Macaca nemestrina). [alpha]-neo-endorphin was the most abundant peptide in both cortex and striatum. The concentrations of all four peptides were significantly greater in the striatum compared to the cortex. In general, concentrations of each peptide tended to be higher in allocortex than in neocortex. Possible inter- and intradomain processing differences, as estimated by ratios of these peptides, did not vary within cortex, but the intradomain peptide ratio, dyn A (1-17)/dyn A (1-8), was significantly greater in cortex than in striatum. These results indicate that prodynorphin is, in some ways, uniquely processed in the primate. Particularly unusual is the relatively low abundance of prodynorphin-derived products in the cortex, in the face of moderately high levels of kappa opiate receptor expression. | en_US |
dc.format.extent | 759088 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Prodynorphin-derived peptide expression in primate cortex and striatum | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of of Psychiatry, Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109-0720, USA | en_US |
dc.contributor.affiliationum | Department of of Psychiatry, Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109-0720, USA | en_US |
dc.identifier.pmid | 7862260 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31211/1/0000113.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0143-4179(94)90108-2 | en_US |
dc.identifier.source | Neuropeptides | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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