Peptides as probes for G protein signal transduction
dc.contributor.author | Taylor, Joan M. | en_US |
dc.contributor.author | Neubig, Richard R. | en_US |
dc.date.accessioned | 2006-04-10T17:48:00Z | |
dc.date.available | 2006-04-10T17:48:00Z | |
dc.date.issued | 1994-11 | en_US |
dc.identifier.citation | Taylor, Joan M., Neubig, Richard R. (1994/11)."Peptides as probes for G protein signal transduction." Cellular Signalling 6(8): 841-849. <http://hdl.handle.net/2027.42/31230> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T2M-47DTYJS-G/2/5bdcfdf41c62ded1235f9bdb3ce6381f | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31230 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7718404&dopt=citation | en_US |
dc.description.abstract | Triggered by agonist binding to cell surface receptors, the heterotrimeric G proteins dissociate into [alpha] and [beta][gamma] subunits, each activating distinct second messenger pathways. Peptides from the primary sequences of receptors, G proteins, and effectors have been used to study the molecular interactions between these proteins. Receptor-derived peptides from the second, third and fourth intracellular loops and certain naturally occurring peptides antagonize G protein interactions and can directly activate G protein. These peptides bind to G protein sites that include the N and C terminal regions of the [alpha] subunit and a yet to be identified region of the [beta] subunit. Peptides have also been useful in characterizing G protein-effector interactions. The identification of the contact sites between proteins involved in G protein signal transduction should aid in the development of non-peptide mimetic therapeutics which could specifically modify G protein-mediated cellular responses. | en_US |
dc.format.extent | 720473 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Peptides as probes for G protein signal transduction | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, M6322 Medical Science Bldg 1, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, M6322 Medical Science Bldg 1, Ann Arbor, MI 48109, U.S.A.; Department of Internal Medicine (Hypertension), University of Michigan, M6322 Medical Science Bldg 1, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 7718404 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31230/1/0000133.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0898-6568(94)90017-5 | en_US |
dc.identifier.source | Cellular Signalling | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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