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Genetic Map of the Region around grizzled (gr) and mocha (mh) on Mouse Chromosome 10, Homologous to Human 19p13.3

dc.contributor.authorKapfhamer, Daviden_US
dc.contributor.authorBurmeister, Margit L.en_US
dc.date.accessioned2006-04-10T17:52:31Z
dc.date.available2006-04-10T17:52:31Z
dc.date.issued1994-10en_US
dc.identifier.citationKapfhamer, David, Burmeister, Margit (1994/10)."Genetic Map of the Region around grizzled (gr) and mocha (mh) on Mouse Chromosome 10, Homologous to Human 19p13.3." Genomics 23(3): 635-642. <http://hdl.handle.net/2027.42/31301>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WG1-45PMS69-DH/2/032d5ba1511ac12d95feb591f1cb4ea5en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/31301
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7851892&dopt=citationen_US
dc.description.abstractGrizzled (gr) is a recessive mouse mutation resulting in a gray coat color and reduced perinatal viability. Mocha (mh) is one of several recessive mouse mutants characterized by platelet storage pool disorder, pigment abnormalities, reduced fertility, kidney function deficiencies, and, in some mutants, inner ear and natural killer cell deficiencies. Murine platelet storage pool deficient mutants may be models for Chediak-Higashi and Hermansky-Pudlak syndromes in humans. The genes for gr and mh are very closely linked to each other (0 +/- 1.2 cM). However, their relative position with respect to molecular markers was previously unknown. Thus, genetic mapping of the gr locus will also yield information about the mh location. To map these two genes genetically, we have performed an intersubspecific backcross of grizzled mice with Mus musculus castaneus. In 539 progeny tested, we found no recombination between the gr gene, the gene for anti-Muellerian hormone (Amh), and the microsatellite markers D10Mit7, D10Mit21, and D10Mit23 . One recombination event for each of the flanking markers Basigin (Bsg) and D10Mit22 was identified. These closely linked markers should provide entry points for positional cloning of the gr and mh genes. The region linked to grizzled is homologous to a gene-rich region on human Chromosome 19p13.3.en_US
dc.format.extent526120 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleGenetic Map of the Region around grizzled (gr) and mocha (mh) on Mouse Chromosome 10, Homologous to Human 19p13.3en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, Michigan, USA.en_US
dc.contributor.affiliationumDepartment of Psychiatry and Department of Human Genetics, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, Michigan, USA.en_US
dc.identifier.pmid7851892en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/31301/1/0000207.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1006/geno.1994.1552en_US
dc.identifier.sourceGenomicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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