The time-course of the induction of reparative dentine formation in monkeys by recombinant human osteogenic protein-1
dc.contributor.author | Rutherford, R. Bruce | en_US |
dc.contributor.author | Spangberg, Larz | en_US |
dc.contributor.author | Tucker, Marjorie | en_US |
dc.contributor.author | Rueger, David | en_US |
dc.contributor.author | Charette, Marc | en_US |
dc.date.accessioned | 2006-04-10T17:52:56Z | |
dc.date.available | 2006-04-10T17:52:56Z | |
dc.date.issued | 1994-10 | en_US |
dc.identifier.citation | Rutherford, R. Bruce, Spangberg, Larz, Tucker, Marjorie, Rueger, David, Charette, Marc (1994/10)."The time-course of the induction of reparative dentine formation in monkeys by recombinant human osteogenic protein-1." Archives of Oral Biology 39(10): 833-838. <http://hdl.handle.net/2027.42/31308> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T4J-4BWF9RT-208/2/fa7a0cb465fb201db19f6287923500b0 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31308 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7741652&dopt=citation | en_US |
dc.description.abstract | Recombinant human osteogenic protein-1 (hOP-1, BMP-7) induces cartilage and bone formation when implanted in extra- and intraskeletal sites in vivo. rOP-1 also preserves pulp vitality and stimulates reparative dentine formation when placed on partially amputated vital dental pulp tissue. The amount of dentine formed in 6 weeks was earlier found to be proportional to the total amount of rOP-1/carrier placed on the pulp and the capacity of the pulp to respond to rOP-1 appeared to be independent of the amount of coronal pulp removed. This reparative dentine was not completely mineralized after 6 weeks healing. Experiments were now made to determine the capacity of hOP-1 to preserve the vitality of and induce reparative dentine in vital radicular pulps. The extent of tissue mineralization present after 1, 2, 4 and 6 months' healing time in permanent monkey teeth was assessed. Radicular pulp vitality was maintained, reparative dentine formed, and mineralization was nearly 75% complete after 1 month and more than 95% after 4 months. The effects of irrigating the exposed pulps with EDTA, sodium hypochlorite or saline were also compared. Significantly more sodium hypochloritetreated pulps became non-vital and the root canals of all the non-vital teeth contained bacteria at the time of sacrifice. | en_US |
dc.format.extent | 662172 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The time-course of the induction of reparative dentine formation in monkeys by recombinant human osteogenic protein-1 | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan School of Dentistry, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationother | University of Connecticut School of Dental Medicine, Farmington, CT 06032, U.S.A. | en_US |
dc.contributor.affiliationother | Creative BioMolecules, Inc., Hopkinton, MA 01748, U.S.A. | en_US |
dc.contributor.affiliationother | Creative BioMolecules, Inc., Hopkinton, MA 01748, U.S.A. | en_US |
dc.contributor.affiliationother | Creative BioMolecules, Inc., Hopkinton, MA 01748, U.S.A. | en_US |
dc.identifier.pmid | 7741652 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31308/1/0000216.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0003-9969(94)90014-0 | en_US |
dc.identifier.source | Archives of Oral Biology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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