Galactosemia produces ARI-preventable nodal changes similar to those of diabetic neuropathy
dc.contributor.author | Kamijo, Mikiko | en_US |
dc.contributor.author | Basso, Michael | en_US |
dc.contributor.author | Varghese Cherian, P. | en_US |
dc.contributor.author | Hohman, Thomas C. | en_US |
dc.contributor.author | Sima, Anders A. F. | en_US |
dc.date.accessioned | 2006-04-10T17:55:02Z | |
dc.date.available | 2006-04-10T17:55:02Z | |
dc.date.issued | 1994-09 | en_US |
dc.identifier.citation | Kamijo, Mikiko, Basso, Michael, Varghese Cherian, P., Hohman, Thomas C., Sima, Anders A. F. (1994/09)."Galactosemia produces ARI-preventable nodal changes similar to those of diabetic neuropathy." Diabetes Research and Clinical Practice 25(2): 117-129. <http://hdl.handle.net/2027.42/31346> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T5Y-4C71D4Y-47/2/526b420e7bde01098a2664a397350056 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31346 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7821191&dopt=citation | en_US |
dc.description.abstract | The present study was designed to examine the development of structural changes, characteristic of diabetic neuropathy, in chronic galactosemia and their responsiveness to inhibition of the polyol-pathway. Sprague-Dawley rats weighing 70-90 g were given a 50% galactose diet continued for 4 or 8 months. Half of these animals were simultaneously given the aldose reductase inhibitor (ARI) WAY 121-509. ARI-treatment normalized galactitol and myoinositol levels in the sciatic nerve. At 4 months, sciatic nerve conduction velocity (NCV) in galactosemic rats was reduced by 30% which was prevented in ARI-treated rats. At 8 months galactosemia reduced NCV to 58% of control values, while ARI-treatment for 8 months improved NCV to 71% of control values. ARI-treatment prevented in galactosemic rats nodal structural changes characteristic of diabetic neuropathy, whereas axonal atrophy was not affected by ARI-treatment, which may in part account for the only partial prevention of the NCV slowing at 8 months. Nerve fiber regeneration was increased 4-fold in ARI-treated rats compared with untreated galactosemic rats. These data suggest that chronic galactosemia produces a neuropathy structurally similar to diabetic neuropathy. The lack of an ARI-treatment effect on axonal atrophy suggests that this defect is not polyol related in galactosemia. | en_US |
dc.format.extent | 1401023 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Galactosemia produces ARI-preventable nodal changes similar to those of diabetic neuropathy | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical Center, 1331 E. Ann Street, Box 0580, Ann Arbor, MI 48109, USA;Michigan Diabetes Research and Training Center, University of Michigan Medical Center, 1331 E. Ann Street, Box 0580, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical Center, 1331 E. Ann Street, Box 0580, Ann Arbor, MI 48109, USA;Michigan Diabetes Research and Training Center, University of Michigan Medical Center, 1331 E. Ann Street, Box 0580, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical Center, 1331 E. Ann Street, Box 0580, Ann Arbor, MI 48109, USA; Department of Internal Medicine, University of Michigan Medical Center, 1331 E. Ann Street, Box 0580, Ann Arbor, MI 48109, USA; Michigan Diabetes Research and Training Center, University of Michigan Medical Center, 1331 E. Ann Street, Box 0580, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Wyeth Ayerst Clinical Research, Princeton, NJ 08543, USA | en_US |
dc.contributor.affiliationother | Wyeth Ayerst Clinical Research, Princeton, NJ 08543, USA | en_US |
dc.identifier.pmid | 7821191 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31346/1/0000256.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0168-8227(94)90037-X | en_US |
dc.identifier.source | Diabetes Research and Clinical Practice | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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