Tyrosine Kinase Inhibitors Attenuate "Capacitative" Ca2+ Influx in Rat Pancreatic Acinar Cells

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dc.contributor.author Yule D. I. , en_US
dc.contributor.author Kim E. T. , en_US
dc.contributor.author Williams J. A. , en_US
dc.date.accessioned 2006-05-10T15:36:59Z
dc.date.available 2006-05-10T15:36:59Z
dc.date.issued 1994-08-15 en_US
dc.identifier.citation Yule D. I., , Kim E. T., , Williams J. A., (1994/08/15)."Tyrosine Kinase Inhibitors Attenuate "Capacitative" Ca2+ Influx in Rat Pancreatic Acinar Cells." Biochemical and Biophysical Research Communications 202(3): 1697-1704. <http://hdl.handle.net/2027.42/31389> en_US
dc.identifier.uri http://www.sciencedirect.com/science/article/B6WBK-45PMMDV-RM/2/8c24736374888998fcb80a75fa669438 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/31389
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8060359&dopt=citation en_US
dc.description.abstract The effect of several tyrosine kinase inhibitors was tested on Ca2+ influx mediated by thapsigargin-and CCh-induced intracellular store depletion. Genestein inhibited Ca2+ influx in a concentration dependent manner without affecting Ca2+ release or Ca2+ pumping activity. A measureable effect was observed at 3 [mu]M with total inhibition of influx seen at 100 [mu]M. Tyrphostin A25 (300 [mu]M; 78% inhibition) and methyl 2,5 dihydroxycinnamate (10 [mu]M; 51% inhibition) also inhibited Ca2+ influx. The degree of attenuation was not markedly altered by preincubation of the inhibitors. Genestein also inhibited Ca2+ influx induced by CCh. These data indicate that inhibition of Ca2+ influx could in part underlie the previously reported inhibition of enzyme secretion by these agents. en_US
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dc.format.extent 3118 bytes
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dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.title Tyrosine Kinase Inhibitors Attenuate "Capacitative" Ca2+ Influx in Rat Pancreatic Acinar Cells en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Natural Resources and Environment en_US
dc.subject.hlbsecondlevel Molecular, Cellular and Developmental Biology en_US
dc.subject.hlbsecondlevel Ecology and Evolutionary Biology en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.subject.hlbtoplevel Science en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum University of Michigan, Sch Med, Dept Physiol, Ann Arbor, MI 48109, USA and Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109, USA en_US
dc.contributor.affiliationum University of Michigan, Sch Med, Dept Physiol, Ann Arbor, MI 48109, USA and Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109, USA en_US
dc.contributor.affiliationum University of Michigan, Sch Med, Dept Physiol, Ann Arbor, MI 48109, USA and Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109, USA en_US
dc.identifier.pmid 8060359 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/31389/3/0000303.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1006/bbrc.1994.2130 en_US
dc.identifier.source Biochemical and Biophysical Research Communications en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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