Asymmetric cross-sensitization to the locomotor stimulant effects of phencyclidine and MK-801,
dc.contributor.author | Xiaojuan Xu, | en_US |
dc.contributor.author | Domino, Edward F. | en_US |
dc.date.accessioned | 2006-04-10T17:58:05Z | |
dc.date.available | 2006-04-10T17:58:05Z | |
dc.date.issued | 1994-08 | en_US |
dc.identifier.citation | Xiaojuan Xu, , Domino, Edward F. (1994/08)."Asymmetric cross-sensitization to the locomotor stimulant effects of phencyclidine and MK-801,." Neurochemistry International 25(2): 155-159. <http://hdl.handle.net/2027.42/31399> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0B-484F1J7-4F/2/c89c00a89da516bc890156e55799884d | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31399 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7994196&dopt=citation | en_US |
dc.description.abstract | Chronic administration of a psychomotor stimulant has been shown to produce progressively enhanced effects, a phenomenon called "reverse tolerance" or sensitization. Sensitization which develops to the psychomotor stimulant effect of a drug generalizes to drugs with similar neurochemical mechanisms of action, a phenomenon called cross-sensitization. The present study compared the psychomotor stimulant effects of phencyclidine and MK-801, examined the effects of the daily injection of phencyclidine and MK-801 on locomotor activity and investigated whether reciprocal cross-sensitization occurred between phencyclidine and MK-801. Adult female Sprague-Dawley rats were used. Their locomotor activity was measured automatically for a 2h period following drug injection. Phencyclidine and MK-801 both increased locomotor activity. Four daily injections of phencyclidine in a dose of 3.2 mg/kg i.p., or MK-801 in a dose of 0.32 mg/kg i.p., produced sensitization to locomotor activity. Moreover, MK-801 sensitized rats showed cross-sensitization to phencyclidine. However, phencyclidine sensitized rats did not show cross-sensitization to MK-801. This finding suggests that there are significant differences in the neurochemical mechanisms underlying phencyclidine-induced and MK-801-induced sensitization. Phencyclidine sensitization may not be mediated by NMDA receptors. | en_US |
dc.format.extent | 457011 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Asymmetric cross-sensitization to the locomotor stimulant effects of phencyclidine and MK-801, | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0626, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0626, U.S.A. | en_US |
dc.identifier.pmid | 7994196 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31399/1/0000314.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0197-0186(94)90034-5 | en_US |
dc.identifier.source | Neurochemistry International | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.