The mitogen activated protein kinase signal transduction pathway: From the cell surface to the nucleus
dc.contributor.author | Guan, Kun-Liang | en_US |
dc.date.accessioned | 2006-04-10T17:59:16Z | |
dc.date.available | 2006-04-10T17:59:16Z | |
dc.date.issued | 1994-08 | en_US |
dc.identifier.citation | Guan, K. -L. (1994/08)."The mitogen activated protein kinase signal transduction pathway: From the cell surface to the nucleus." Cellular Signalling 6(6): 581-589. <http://hdl.handle.net/2027.42/31420> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T2M-47NVKY0-39/2/a20413adc99953c906183ddc832b7f31 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31420 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7857762&dopt=citation | en_US |
dc.description.abstract | Activation of the mitogen activated protein kinase (MAPK) plays esential roles in many signal transduction pathways. MAPK has been demonstrated to phosphorylate and regulate numerous cellular proteins, including growth factor receptor, transcription factors, cytoskeletal proteins, phospholipase and other protein kinases. Activation of MAPK requires phosphorylation of both threonine and tyrosine residues, which are catalysed by a single protein kinase known as MAPK kinase or MEK. MEK itself is activated by phosphorylation on two conserved serine residues. Three distinct mammalian Ser/Thr kinases, including Raf, Mos and MEKK (for MEK kinase), have been demonstrated to phosphorylate and activate MEK. The MAP kinase cascade is highly conserved in all eukaryotes and involved in numerous cellular responses. Activation of MAPK is a transient event that is tightly regulated by both kinases and phosphatases. A growth factor induced dual specific phosphatase is likely to play an important role in MAPK regulation. | en_US |
dc.format.extent | 673168 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The mitogen activated protein kinase signal transduction pathway: From the cell surface to the nucleus | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry and the Institute of Gerontology, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 7857762 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31420/1/0000337.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0898-6568(94)90041-8 | en_US |
dc.identifier.source | Cellular Signalling | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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