Withdrawal from morphine or amphetamine: different effects on dopamine in the ventral-medial striatum studied with microdialysis
dc.contributor.author | Crippens, Donita | en_US |
dc.contributor.author | Robinson, Terry E. | en_US |
dc.date.accessioned | 2006-04-10T18:00:42Z | |
dc.date.available | 2006-04-10T18:00:42Z | |
dc.date.issued | 1994-07-04 | en_US |
dc.identifier.citation | Crippens, Donita, Robinson, Terry E. (1994/07/04)."Withdrawal from morphine or amphetamine: different effects on dopamine in the ventral-medial striatum studied with microdialysis." Brain Research 650(1): 56-62. <http://hdl.handle.net/2027.42/31444> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-4835Y66-12Y/2/216b6575a91e442d1d08a70d80d68da3 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31444 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7953677&dopt=citation | en_US |
dc.description.abstract | The effect of withdrawal from chronic morphine or amphetamine treatment on dopamine (DA) neurotransmission in the ventral-medial striatum was studied by use of in vivo microdialysis. There was no effect of 24 h of amphetamine withdrawal on the basal concentration of DA in the ventral-medial striatum. Spontaneous morphine withdrawal (24 h) was associated with a significant decrease in the basal concentration of DA in dialysate, but following morphine replacement and naloxone-precipitated withdrawal variations in withdrawal symptoms were not related to variations in the concentration of DA in dialysate. It is suggested that: (1) the correlation between the extracellular concentration of DA in the ventral-medial striatum and the symptoms of morphine withdrawal may not be indicative of a necessary, causal relationship; and (2) a decrease in the extracellular concentration of DA in the ventral-medial striatum is not a common feature of drug withdrawal syndromes. | en_US |
dc.format.extent | 664989 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Withdrawal from morphine or amphetamine: different effects on dopamine in the ventral-medial striatum studied with microdialysis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychology and Neuroscience Program, Neuroscience Laboratory Building, The University of Michigan, 1103 E. Huron Street, Ann Arbor, MI 48104-1687, USA | en_US |
dc.contributor.affiliationum | Department of Psychology and Neuroscience Program, Neuroscience Laboratory Building, The University of Michigan, 1103 E. Huron Street, Ann Arbor, MI 48104-1687, USA | en_US |
dc.identifier.pmid | 7953677 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31444/1/0000364.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(94)90206-2 | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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