Intratracheal Administration of Endotoxin and Cytokines : VII. The Soluble Interleukin-1 Receptor and the Soluble Tumor Necrosis Factor Receptor II (p80) Inhibit Acute Inflammation
dc.contributor.author | Ulich, Thomas R. | en_US |
dc.contributor.author | Yi, Eunhee S. | en_US |
dc.contributor.author | Yin, Songmei | en_US |
dc.contributor.author | Smith, Craig | en_US |
dc.contributor.author | Remick, Daniel G. | en_US |
dc.date.accessioned | 2006-04-10T18:01:48Z | |
dc.date.available | 2006-04-10T18:01:48Z | |
dc.date.issued | 1994-07 | en_US |
dc.identifier.citation | Ulich, Thomas R., Yi, Eunhee S., Yin, Songmei, Smith, Craig, Remick, Daniel (1994/07)."Intratracheal Administration of Endotoxin and Cytokines : VII. The Soluble Interleukin-1 Receptor and the Soluble Tumor Necrosis Factor Receptor II (p80) Inhibit Acute Inflammation." Clinical Immunology and Immunopathology 72(1): 137-140. <http://hdl.handle.net/2027.42/31462> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WCK-45P0WN1-42/2/eb7da994d6da0367bc68eff055b614e8 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31462 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8020186&dopt=citation | en_US |
dc.description.abstract | Intratracheal administration of endotoxin (LPS) causes acute neutrophilic inflammation via induction of pulmonary tumor necrosis factor [alpha] (TNF) and interleukin-1 (IL-1) expression. In the present study, the anti-inflammatory activity of soluble IL-1 receptor (sIL-1r) and soluble TNF receptor p80 (sTNFr-p80) in LPS-induced acute pulmonary inflammation was investigated. The sIL-1r coinjected intratracheally with LPS in rats significantly inhibits neutrophilic exudation into bronchoalveolar lavage (BAL) fluid by 47% after 6 hr compared to injection of LPS alone. TNF and IL-6 in the same BAL fluids were both lowered by approximately 50% after intratracheal coinjection of sIL-1r and LPS as compared to LPS alone. In the same model, the sTNFr-p80 inhibited acute inflammation. Paradoxically, TNF levels in BAL fluids were generally elevated after the intratracheal coinjectiun of LPS and monomeric sTNFr-p80 compared to injection of LPS injection alone. The combined anti-inflammatory effect of sIL-1r and sTNFr-p80 at the maximally effective individual doses is not significantly greater than the effect of either soluble receptor alone. | en_US |
dc.format.extent | 262856 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Intratracheal Administration of Endotoxin and Cytokines : VII. The Soluble Interleukin-1 Receptor and the Soluble Tumor Necrosis Factor Receptor II (p80) Inhibit Acute Inflammation | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of California at San Diego School of Medicine, San Diego, California; Immunex Corporation, Seattle, Washington; and Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Pathology, University of California at San Diego School of Medicine, San Diego, California | en_US |
dc.contributor.affiliationother | Department of Pathology, University of California at San Diego School of Medicine, San Diego, California | en_US |
dc.contributor.affiliationother | Immunex Corporation, Seattle, Washington | en_US |
dc.identifier.pmid | 8020186 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31462/1/0000384.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1006/clin.1994.1117 | en_US |
dc.identifier.source | Clinical Immunology and Immunopathology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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