Treatment of Alprazolam withdrawal with chlordiazepoxide substitution and taper
dc.contributor.author | Closser, Mary H. | en_US |
dc.contributor.author | Brower, Kirk J. | en_US |
dc.date.accessioned | 2006-04-10T18:02:44Z | |
dc.date.available | 2006-04-10T18:02:44Z | |
dc.date.issued | 1994 | en_US |
dc.identifier.citation | Closser, Mary H., Brower, Kirk J. (1994)."Treatment of Alprazolam withdrawal with chlordiazepoxide substitution and taper." Journal of Substance Abuse Treatment 11(4): 319-323. <http://hdl.handle.net/2027.42/31476> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T90-460XJFF-3M/2/44674cd70414d86a6fa2a6f21301fe00 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31476 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7966502&dopt=citation | en_US |
dc.description.abstract | We describe the first case series (n = 6) of using chlordiazepoxide to accomplish a rapid, well-tolerated withdrawal from alprazolam. After abruptly discontinuing alprazolam, we substituted a 50-mg dose of chlordiazepoxide for each 1 mg of alprazolam (except for one elderly patient where we substituted 25 mg) and gave additional chlordiazepoxide doses (25-50 mg every 4-6 hours) as needed for the first 1-2 days of hospitalization. With this approach, the mean "substitution ratio" of chlordiazepoxide to alprazolam was 86 to 1. We then tapered chlordiazepoxide by an average of 10% each day over a 7- to 14-day period according to the symptoms manifested and tolerated by individual patients. No seizures or other serious side effects occurred. Incomplete cross- dependence, as described elsewhere in the literature, was not observed. The rapidity and familiarity of the method are advantages for inpatient units, but careful titration of dosage, diagnostic clarity, and extended follow-ups are necessary when applying this approach. | en_US |
dc.format.extent | 620381 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Treatment of Alprazolam withdrawal with chlordiazepoxide substitution and taper | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Substance Abuse Clinic, Department of Veterans Affairs Medical Center, Ann Arbor, Michigan, USA; Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; Chelsea Arbor Treatment Center, Chelsea, Michigan, USA | en_US |
dc.identifier.pmid | 7966502 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31476/1/0000398.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0740-5472(94)90042-6 | en_US |
dc.identifier.source | Journal of Substance Abuse Treatment | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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