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The mode of action of antimalarial endoperoxides

dc.contributor.authorMeshnick, Steven R.en_US
dc.date.accessioned2006-04-10T18:04:57Z
dc.date.available2006-04-10T18:04:57Z
dc.date.issued1994-06en_US
dc.identifier.citationMeshnick, Steven R. (1994/06)."The mode of action of antimalarial endoperoxides." Transactions of the Royal Society of Tropical Medicine and Hygiene 88(Supplement 1): 31-32. <http://hdl.handle.net/2027.42/31511>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B75GP-4C0KBD7-1H2/2/d5377f337082cdcca43b291ca7a49731en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/31511
dc.description.abstractThe mechanism of action of artemisinin appears to involve two steps. In the first step, activation, intra-parasitic iron catalyses the cleavage of the endoperoxide bridge and the generation of free radicals. In the second step, alkylation, the artemisinin-derived free radical forms covalent bonds with parasite proteins.en_US
dc.format.extent207161 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleThe mode of action of antimalarial endoperoxidesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USAen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/31511/1/0000433.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0035-9203(94)90468-5en_US
dc.identifier.sourceTransactions of the Royal Society of Tropical Medicine and Hygieneen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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