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F-actin, tubulin and spectrin in the organ of Corti: Comparative distribution in different cell types and mammalian species

dc.contributor.authorRaphael, Yehoashen_US
dc.contributor.authorAthey, Brian D.en_US
dc.contributor.authorYu Wang,en_US
dc.contributor.authorLee, Michael K.en_US
dc.contributor.authorAltschuler, Richard A.en_US
dc.date.accessioned2006-04-10T18:05:35Z
dc.date.available2006-04-10T18:05:35Z
dc.date.issued1994-06-01en_US
dc.identifier.citationRaphael, Yehoash, Athey, Brian D., Yu Wang, , Lee, Michael K., Altschuler, Richard A. (1994/06/01)."F-actin, tubulin and spectrin in the organ of Corti: Comparative distribution in different cell types and mammalian species." Hearing Research 76(1-2): 173-187. <http://hdl.handle.net/2027.42/31521>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T73-485PD0C-5T/2/37549ee026722fa1e1e368575e92fd75en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/31521
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7928710&dopt=citationen_US
dc.description.abstractLaser scanning confocal microscopy was used to determine the distribution of actin, spectrin and tubulin in whole mounts of the organ of Corti of guinea pig, monkey, rat and chinchilla. Actin, spectrin and tubulin were localized in all cell types in the auditory epithelium. No specialized cytoskeletal organization of tubulin was detected in the cytoplasmic domain of hair cells. The only specialized organization of actin and spectrin in the cytoplasmic domain was the infra-cuticular network, found exclusively in apical guinea pig outer hair cells. In contrast, the lateral wall of inner and outer hair cells contained a homogenous distribution of label specific for actin and spectrin. The label intensity was similar in the base and the apex of the cochlea. These results indicate that the distribution of spectrin and actin in the auditory epithelium is similar to that in other epithelial cells, suggesting that actin and spectrin participate in the formation of cellular shape and possibly in docking molecules to the membrane.en_US
dc.format.extent1739261 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleF-actin, tubulin and spectrin in the organ of Corti: Comparative distribution in different cell types and mammalian speciesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumKresge Hearing Research Institute, The University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-0506, USAen_US
dc.contributor.affiliationumKresge Hearing Research Institute, The University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-0506, USAen_US
dc.contributor.affiliationumno department Kresge Hearing Research Institute, The University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-0506, USAen_US
dc.contributor.affiliationumKresge Hearing Research Institute, The University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-0506, USAen_US
dc.contributor.affiliationumKresge Hearing Research Institute, The University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-0506, USAen_US
dc.identifier.pmid7928710en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/31521/1/0000443.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0378-5955(94)90098-1en_US
dc.identifier.sourceHearing Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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