Exponential Regression of CA 125 during Salvage Treatment of Ovarian Cancer with Taxol
dc.contributor.author | Pearl, Michael L. | en_US |
dc.contributor.author | Yashar, Catheryn M. | en_US |
dc.contributor.author | Johnston, Carolyn M. | en_US |
dc.contributor.author | Reynolds, R. Kevin | en_US |
dc.contributor.author | Roberts, James A. | en_US |
dc.date.accessioned | 2006-04-10T18:07:09Z | |
dc.date.available | 2006-04-10T18:07:09Z | |
dc.date.issued | 1994-06 | en_US |
dc.identifier.citation | Pearl, Michael L., Yashar, Catheryn M., Johnston, Carolyn M., Reynolds, R. Kevin, Roberts, James A. (1994/06)."Exponential Regression of CA 125 during Salvage Treatment of Ovarian Cancer with Taxol." Gynecologic Oncology 53(3): 339-343. <http://hdl.handle.net/2027.42/31547> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WG6-45NJYX8-6V/2/fb3bed1ead1b0eba1db2d129237facff | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/31547 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7911444&dopt=citation | en_US |
dc.description.abstract | The role of serum CA 125 in monitoring the response of epithelial ovarian cancer to treatment has been extensively investigated. The exponential regression curve [ln(CA 125) = i + s (days after initiation of treatment)] has been reported to describe the rate of change of serum CA 125 during treatment. In this model, the y-axis intercept (i) represents the initial CA 125-secreting tumor burden, while the slope (s) is determined by the response to treatment. The exponential regression curve was calculated for 66 patients undergoing salvage chemotherapy with taxol. At a mean follow-up of 121 days, 50 (75%) patients had progressed and 35 (53%) had died. Stratification of the patients by stage, grade, or histology did not reveal any significant differences in the regression rate. When the patients were stratified by response, the mean regression rate was 0.0157 +/- 0.011 for patients with progressive disease (N = 19) vs -0.0250 +/- 0.031 for those with stable disease (N = 25) and -0.0250 +/- 0.015 for those with a partial response (N = 22) (P P > 0.05). We conclude that changes in serum CA 125 levels follow an exponential regression curve in patients undergoing salvage chemotherapy with taxol for progressive or recurrent ovarian cancer. A positive regression rate may predict which patients will progress prior to the time progression becomes clinically evident. However, a negative rate fails to provide discriminatory utility in predicting progression-free interval or survival. | en_US |
dc.format.extent | 264470 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Exponential Regression of CA 125 during Salvage Treatment of Ovarian Cancer with Taxol | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbsecondlevel | Ophthalmology | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Obstetrics and Gynecology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Medical Professional Building, Room D2202-0718, 1500 East Medical Center Drive, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0718 | en_US |
dc.contributor.affiliationum | Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Medical Professional Building, Room D2202-0718, 1500 East Medical Center Drive, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0718 | en_US |
dc.contributor.affiliationum | Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Medical Professional Building, Room D2202-0718, 1500 East Medical Center Drive, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0718 | en_US |
dc.contributor.affiliationum | Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Medical Professional Building, Room D2202-0718, 1500 East Medical Center Drive, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0718 | en_US |
dc.contributor.affiliationum | Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Medical Professional Building, Room D2202-0718, 1500 East Medical Center Drive, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0718 | en_US |
dc.identifier.pmid | 7911444 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/31547/1/0000470.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1006/gyno.1994.1144 | en_US |
dc.identifier.source | Gynecologic Oncology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.