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Resistance to nitroprusside neurotoxicity in perinatal rat brain
dc.contributor.authorMaragos, William F.en_US
dc.contributor.authorSilverstein, Faye Sarahen_US
dc.date.accessioned2006-04-10T18:08:44Z
dc.date.available2006-04-10T18:08:44Z
dc.date.issued1994-05-19en_US
dc.identifier.citationMaragos, William F., Silverstein, Faye S. (1994/05/19)."Resistance to nitroprusside neurotoxicity in perinatal rat brain." Neuroscience Letters 172(1-2): 80-84. <http://hdl.handle.net/2027.42/31573>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0G-482XKB1-K4/2/b7e1db9dfbab13322924c9781c89ee11en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/31573
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8084542&dopt=citationen_US
dc.description.abstractNitric oxide (NO) may mediate some of the toxic effects of the excitatory amino acid (EAA) glutamate when there is overactivation of the (NMDA) receptor. In the developing rodent nervous system, NMDA neurotoxicity peaks at postnatal day 7. To assess whether NO toxicity exhibits a similar developmental profile, we injected the NO generator sodium nitroprusside into the immature and adult rodent hippocampal formation and striatum, using a dose known to damage the adult nervous system. Contrary to our expectations, we found the immature brain highly resistant to the toxic effects of sodium nitroprusside.en_US
dc.format.extent486609 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleResistance to nitroprusside neurotoxicity in perinatal rat brainen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment Neurology, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment Pediatrics, University of Michigan, Ann Arbor, MI, USAen_US
dc.identifier.pmid8084542en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/31573/1/0000501.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0304-3940(94)90667-Xen_US
dc.identifier.sourceNeuroscience Lettersen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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