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Biological effects of a novel intestinal peptide -- inhibiting enterocytogenin on cultured 3T3 mouse fibroblasts and L5178Y mouse lymphoma cells
dc.contributor.authorTrifonov, Borislav B.en_US
dc.contributor.authorRousev, George K.en_US
dc.contributor.authorArgirov, Ognjanen_US
dc.contributor.authorDraganov, Marian M.en_US
dc.contributor.authorKamberov, Emmanuel S.en_US
dc.date.accessioned2006-04-10T18:09:17Z
dc.date.available2006-04-10T18:09:17Z
dc.date.issued1994-05-05en_US
dc.identifier.citationTrifonov, Borislav B., Rousev, George K., Argirov, Ognjan, Draganov, Marian M., Kamberov, Emmanuel S. (1994/05/05)."Biological effects of a novel intestinal peptide -- inhibiting enterocytogenin on cultured 3T3 mouse fibroblasts and L5178Y mouse lymphoma cells." Regulatory Peptides 51(2): 111-119. <http://hdl.handle.net/2027.42/31582>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0S-47GGSJS-55/2/19c50429fdbf6b191aaef8f33d1a0ce2en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/31582
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8059007&dopt=citationen_US
dc.description.abstractThe effects of a new intestinal peptide, inhibiting enterocytogenin (IEG) derived from pig intestinal mucosa were studied in vitro on 3T3 mouse fibroblasts and L5178Y mouse lymphoma cell line. IEG caused considerable growth inhibition together with specific morphological changes, necrotic effects as well as formation of monolayers at the highest concentration applied (1000 [mu]g/ml). A biologically active fraction (IEG-BAF) derived by further purification of IEG by gel-filtration, proved to possess most of the described activity. The concentrations of IEG and IEG-BAF inhibiting the growth of L5178Y lymphoma cells by 50% (IC50 values) were calculated to be 759 [mu]g/ml and 192 [mu]g/ml, respectively. IEG-BAF has a molecular mass of 4450 +/- 180 Da and is most probably a peptidylnucleotidate as revealed by spectral analysis.en_US
dc.format.extent719275 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleBiological effects of a novel intestinal peptide -- inhibiting enterocytogenin on cultured 3T3 mouse fibroblasts and L5178Y mouse lymphoma cellsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biological Chemistry, University of Michigan Medical School, Medical Science I, 1301 Catherine Rd., Ann Arbor, MI 48109-0606, USAen_US
dc.contributor.affiliationotherDepartment of Physiology, Medical University, 4000, Plovdiv, Bulgariaen_US
dc.contributor.affiliationotherDepartment of Physiology, Medical University, 4000, Plovdiv, Bulgariaen_US
dc.contributor.affiliationotherDepartments of Organic Chemistry and Cell Biology, Paisji Hilendarski University of Plovdiv, 4000, Plovdiv, Bulgariaen_US
dc.contributor.affiliationotherDepartments of Organic Chemistry and Cell Biology, Paisji Hilendarski University of Plovdiv, 4000, Plovdiv, Bulgariaen_US
dc.identifier.pmid8059007en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/31582/1/0000511.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0167-0115(94)90200-3en_US
dc.identifier.sourceRegulatory Peptidesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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